Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052379990> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2052379990 endingPage "479" @default.
- W2052379990 startingPage "479" @default.
- W2052379990 abstract "Among harmful conditions damaging the blood–brain barrier, cerebral stroke and reperfusion injuries were proposed as contributing factors to Alzheimer's disease etiology. Indeed it was reported that ischemic conditions promote β-amyloid peptide production in brain endothelial cells, although implicated mechanisms are yet not fully understood.Oxidative injury related to ischemia affects membrane-lipids profile by altering their biochemical properties and structural dynamics, which are also believed to play significant role in the amyloid precursor protein processing, suggesting a link between alterations in lipid membrane composition and β-amyloid peptide production enhancement.Using brain microvascular endothelial cells, here we demonstrate how oxygen and glucose deprivation followed by normal conditions restoration, mimicking ischemic environment, increases cell cholesterol amount (+20%), reduces membrane fluidity and results in strong activation (+40%) of β-secretase 1 enzymatic activity. Moreover, we observed an increase of amyloid precursor protein and β-secretase 1 protein levels with altered localization in non-discrete (Triton X-100 soluble) membrane domains, leading to an enhanced production of amyloid precursor protein β-carboxyl-terminal fragment. Therefore, lipid alterations induced by oxygen and glucose deprivation enhance β-secretase 1 activity, favor its proximity to amyloid precursor protein and may concur to increased amyloidogenic cleavage. The latter, represents a detrimental event that may contribute to β-amyloid homeostasis impairment in the brain and to Alzheimer's disease-related BBB dysfunctions." @default.
- W2052379990 created "2016-06-24" @default.
- W2052379990 creator A5025109546 @default.
- W2052379990 creator A5055999329 @default.
- W2052379990 date "2010-04-01" @default.
- W2052379990 modified "2023-09-24" @default.
- W2052379990 title "Mechanisms of inflammation" @default.
- W2052379990 doi "https://doi.org/10.1016/j.biocel.2010.02.001" @default.
- W2052379990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20138153" @default.
- W2052379990 hasPublicationYear "2010" @default.
- W2052379990 type Work @default.
- W2052379990 sameAs 2052379990 @default.
- W2052379990 citedByCount "2" @default.
- W2052379990 countsByYear W20523799902017 @default.
- W2052379990 countsByYear W20523799902020 @default.
- W2052379990 crossrefType "journal-article" @default.
- W2052379990 hasAuthorship W2052379990A5025109546 @default.
- W2052379990 hasAuthorship W2052379990A5055999329 @default.
- W2052379990 hasConcept C126322002 @default.
- W2052379990 hasConcept C177907266 @default.
- W2052379990 hasConcept C179104552 @default.
- W2052379990 hasConcept C185592680 @default.
- W2052379990 hasConcept C203014093 @default.
- W2052379990 hasConcept C2776914184 @default.
- W2052379990 hasConcept C2777633098 @default.
- W2052379990 hasConcept C2779134260 @default.
- W2052379990 hasConcept C31705614 @default.
- W2052379990 hasConcept C36103677 @default.
- W2052379990 hasConcept C502032728 @default.
- W2052379990 hasConcept C55493867 @default.
- W2052379990 hasConcept C71924100 @default.
- W2052379990 hasConcept C86803240 @default.
- W2052379990 hasConcept C95444343 @default.
- W2052379990 hasConceptScore W2052379990C126322002 @default.
- W2052379990 hasConceptScore W2052379990C177907266 @default.
- W2052379990 hasConceptScore W2052379990C179104552 @default.
- W2052379990 hasConceptScore W2052379990C185592680 @default.
- W2052379990 hasConceptScore W2052379990C203014093 @default.
- W2052379990 hasConceptScore W2052379990C2776914184 @default.
- W2052379990 hasConceptScore W2052379990C2777633098 @default.
- W2052379990 hasConceptScore W2052379990C2779134260 @default.
- W2052379990 hasConceptScore W2052379990C31705614 @default.
- W2052379990 hasConceptScore W2052379990C36103677 @default.
- W2052379990 hasConceptScore W2052379990C502032728 @default.
- W2052379990 hasConceptScore W2052379990C55493867 @default.
- W2052379990 hasConceptScore W2052379990C71924100 @default.
- W2052379990 hasConceptScore W2052379990C86803240 @default.
- W2052379990 hasConceptScore W2052379990C95444343 @default.
- W2052379990 hasIssue "4" @default.
- W2052379990 hasLocation W20523799901 @default.
- W2052379990 hasLocation W20523799902 @default.
- W2052379990 hasOpenAccess W2052379990 @default.
- W2052379990 hasPrimaryLocation W20523799901 @default.
- W2052379990 hasRelatedWork W1585690852 @default.
- W2052379990 hasRelatedWork W1985972444 @default.
- W2052379990 hasRelatedWork W2005967565 @default.
- W2052379990 hasRelatedWork W2023782612 @default.
- W2052379990 hasRelatedWork W2094652904 @default.
- W2052379990 hasRelatedWork W2121566293 @default.
- W2052379990 hasRelatedWork W2157810374 @default.
- W2052379990 hasRelatedWork W2956880640 @default.
- W2052379990 hasRelatedWork W3119714211 @default.
- W2052379990 hasRelatedWork W3181770910 @default.
- W2052379990 hasVolume "42" @default.
- W2052379990 isParatext "false" @default.
- W2052379990 isRetracted "false" @default.
- W2052379990 magId "2052379990" @default.
- W2052379990 workType "article" @default.