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- W2052387454 abstract "Evaluation of risk factors in prenatal diagnosis of AVSD and their influence on fetal and neonatal follow up. 69 fetuses with AVSD from 2 referral centers for fetal cardiology. Mean gestational age of the first echo was 27 weeks. 45 fetuses were referred because of abnormal 4-chamber view. 40 mothers were from low-risk group. Karyotype was evaluated in 60 (87%) cases. Fetuses were divided in two groups: Group I – different types of AVSD (53 cases), Group II – heterotaxy syndromes (HS, 16 cases). Group I: balanced AVSD – 37, unbalanced – 16 (with RV dominance – 8 cases, with LV dominance-3, with TOF-5). Group II: left atrial isomerism – 13, right atrial isomerism – 3. Extracardiac malformations were found in 37 fetuses in both groups. All fetuses with HS had normal karyotype, 7 had complete heart block, 4 – other types of arrhythmia. There were 35 (66%) fetuses with chromosomal anomalies in Group I: trisomy 21–21 cases, trisomy 18 – 11, trisomy 13 – 1, Turner – 1, triploidy – 1. In Group I: termination of pregnancy (TOP) – 8, intrauterine demise (IUD) – 5, neonatal or infant deaths – 23 cases, 17 neonates survived. In the Group II: IUD – 4 cases, neonatal or infant death – 7. There are 4 survivors, 1 pregnancy continues. Survival rate is 32% in the Group 1 and 25% in the Group 2. 1. Majority of fetuses with AVSD was referred due to abnormal 4-chamber in low-risk group. 2. Prenatal karyotyping is necessary when AVSD is diagnosed. 3. Fetuses with HS can be excluded from karyotyping in cases when other ultrasound markers of chromosomal abnormalities are not found. 4. TOP rate was low, which was due to late diagnosis, as well as ethical background of the examined families. 5. Survival rate among fetuses with AVSD was much lower when comparing with surgical series in children (mortality rate no more that 15%). 6. Low survival rate must be considered when counseling parents." @default.
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- W2052387454 date "2004-08-01" @default.
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- W2052387454 title "P01.12: Prenatal risk factors influencing outcome of fetuses with atrio-ventricular septal defects" @default.
- W2052387454 doi "https://doi.org/10.1002/uog.1319" @default.
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