Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052388933> ?p ?o ?g. }
- W2052388933 endingPage "100" @default.
- W2052388933 startingPage "71" @default.
- W2052388933 abstract "Autophagy is a stress-induced cell survival program whereby cells under metabolic, proteotoxic, or other stress remove dysfunctional organelles and/or misfolded/polyubiquitylated proteins by shuttling them via specialized structures called autophagosomes to the lysosome for degradation. The end result is the release of free amino acids and metabolites for use in cell survival. For tumor cells, autophagy is a double-edged sword: autophagy genes are frequently mono-allelically deleted, silenced, or mutated in human tumors, resulting in an environment of increased oxidative stress that is conducive to DNA damage, genomic instability, and tumor progression. As such, autophagy is tumor suppressive. In contrast, it is important to note that although tumor cells have reduced levels of autophagy, they do not eliminate this pathway completely. Furthermore, the exposure of tumor cells to an environment of increased metabolic and other stresses renders them reliant on basal autophagy for survival. Therefore, autophagy inhibition is an active avenue for the identification of novel anti-cancer therapies. Not surprisingly, the field of autophagy and cancer has experienced an explosion of research in the past 10 years. This review covers the basic mechanisms of autophagy, discusses its role in tumor suppression and cancer therapy, and posits emerging questions for the future." @default.
- W2052388933 created "2016-06-24" @default.
- W2052388933 creator A5011080677 @default.
- W2052388933 creator A5051241468 @default.
- W2052388933 creator A5065953131 @default.
- W2052388933 creator A5066307003 @default.
- W2052388933 creator A5088200304 @default.
- W2052388933 date "2011-01-01" @default.
- W2052388933 modified "2023-10-03" @default.
- W2052388933 title "Autophagy in tumor suppression and cancer therapy" @default.
- W2052388933 cites W126188432 @default.
- W2052388933 cites W1501966284 @default.
- W2052388933 cites W1512227914 @default.
- W2052388933 cites W1526993239 @default.
- W2052388933 cites W1532433391 @default.
- W2052388933 cites W1549490607 @default.
- W2052388933 cites W1555054913 @default.
- W2052388933 cites W1578979147 @default.
- W2052388933 cites W1780295430 @default.
- W2052388933 cites W1784425676 @default.
- W2052388933 cites W1789901929 @default.
- W2052388933 cites W1918384196 @default.
- W2052388933 cites W1963521777 @default.
- W2052388933 cites W1964032090 @default.
- W2052388933 cites W1964052965 @default.
- W2052388933 cites W1964257510 @default.
- W2052388933 cites W1965383359 @default.
- W2052388933 cites W1966134982 @default.
- W2052388933 cites W1967085696 @default.
- W2052388933 cites W1967743942 @default.
- W2052388933 cites W1970101770 @default.
- W2052388933 cites W1970426263 @default.
- W2052388933 cites W1970637701 @default.
- W2052388933 cites W1971234510 @default.
- W2052388933 cites W1971510147 @default.
- W2052388933 cites W1971664835 @default.
- W2052388933 cites W1971832552 @default.
- W2052388933 cites W1972618720 @default.
- W2052388933 cites W1975981696 @default.
- W2052388933 cites W1977120300 @default.
- W2052388933 cites W1977767269 @default.
- W2052388933 cites W1979228758 @default.
- W2052388933 cites W1979526109 @default.
- W2052388933 cites W1982659569 @default.
- W2052388933 cites W1983287446 @default.
- W2052388933 cites W1983831622 @default.
- W2052388933 cites W1984736455 @default.
- W2052388933 cites W1986536654 @default.
- W2052388933 cites W1986911872 @default.
- W2052388933 cites W1987105275 @default.
- W2052388933 cites W1992643412 @default.
- W2052388933 cites W1992659717 @default.
- W2052388933 cites W1994411647 @default.
- W2052388933 cites W1994980226 @default.
- W2052388933 cites W1996068251 @default.
- W2052388933 cites W1996593753 @default.
- W2052388933 cites W1997714593 @default.
- W2052388933 cites W1998948328 @default.
- W2052388933 cites W1999795482 @default.
- W2052388933 cites W2001284886 @default.
- W2052388933 cites W2001569984 @default.
- W2052388933 cites W2002288000 @default.
- W2052388933 cites W2004994658 @default.
- W2052388933 cites W2005142336 @default.
- W2052388933 cites W2005997790 @default.
- W2052388933 cites W2008898220 @default.
- W2052388933 cites W2009886463 @default.
- W2052388933 cites W2011282245 @default.
- W2052388933 cites W2011580247 @default.
- W2052388933 cites W2012451546 @default.
- W2052388933 cites W2014177248 @default.
- W2052388933 cites W2014840658 @default.
- W2052388933 cites W2014918593 @default.
- W2052388933 cites W2016850819 @default.
- W2052388933 cites W2017230136 @default.
- W2052388933 cites W2019178802 @default.
- W2052388933 cites W2022451432 @default.
- W2052388933 cites W2022812113 @default.
- W2052388933 cites W2024538345 @default.
- W2052388933 cites W2025192214 @default.
- W2052388933 cites W2025714022 @default.
- W2052388933 cites W2026736394 @default.
- W2052388933 cites W2027642343 @default.
- W2052388933 cites W2027846671 @default.
- W2052388933 cites W2033332037 @default.
- W2052388933 cites W2033603289 @default.
- W2052388933 cites W2034339677 @default.
- W2052388933 cites W2034546318 @default.
- W2052388933 cites W2036621981 @default.
- W2052388933 cites W2037967087 @default.
- W2052388933 cites W2039366561 @default.
- W2052388933 cites W2040157483 @default.
- W2052388933 cites W2041811289 @default.
- W2052388933 cites W2042461504 @default.
- W2052388933 cites W2044138885 @default.
- W2052388933 cites W2044504047 @default.
- W2052388933 cites W2044722165 @default.
- W2052388933 cites W2046879630 @default.