FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052398791> ?p ?o ?g. }

• W2052398791 endingPage "331" @default.
• W2052398791 startingPage "313" @default.
• W2052398791 abstract "APOE4 allele is a major risk factor for late-onset Alzheimer disease (AD). The mechanism of action of APOE in AD remains unclear. To study the effects of APOE alleles on gene expression in AD, we have analyzed the gene transcription patterns of human hippocampus from APOE3/3, APOE3/4, APOE4/4 AD patients and normal control using Serial Analysis of Gene Expression (SAGE). Using SAGE, we found gene expression patterns in hippocampus of APOE3/4 and APOE4/4 AD patients differ substantially from those of APOE3/3 AD patients. APOE3/4 and APOE4/4 allele expression may activate similar genes or gene pools with associated functions. APOE4 AD alleles activate multiple tumor suppressors, tumor inducers and negative regulator of cell growth or repressors that may lead to increased cell arrest, senescence and apoptosis. In contrast, there is decreased expression of large clusters of genes associated with synaptic plasticity, synaptic vesicle docking and fusing and axonal/neuronal outgrowth. In addition, reduction of neurotransmitter receptors and Ca2+ homeostasis, disruption of multiple signal transduction pathways, loss of cell protection, and perhaps most notably, mitochondrial oxidative phosphorylation/energy metabolism are associated with APOE3/4 and APOE4/4 AD alleles. These findings may help define the mechanisms that APOE4 contribute that increase risk for AD and identify new candidate genes conferring susceptibility to AD." @default.
• W2052398791 created "2016-06-24" @default.
• W2052398791 creator A5000687935 @default.
• W2052398791 creator A5014103338 @default.
• W2052398791 creator A5017204895 @default.
• W2052398791 creator A5020266650 @default.
• W2052398791 creator A5031025675 @default.
• W2052398791 creator A5035618662 @default.
• W2052398791 creator A5043275152 @default.
• W2052398791 creator A5044048238 @default.
• W2052398791 creator A5063322614 @default.
• W2052398791 creator A5069324665 @default.
• W2052398791 creator A5076559170 @default.
• W2052398791 creator A5076736767 @default.
• W2052398791 creator A5079863158 @default.
• W2052398791 creator A5081512040 @default.
• W2052398791 date "2007-11-01" @default.
• W2052398791 modified "2023-10-09" @default.
• W2052398791 title "A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease" @default.
• W2052398791 cites W1504034796 @default.
• W2052398791 cites W1560623477 @default.
• W2052398791 cites W185521845 @default.
• W2052398791 cites W1968877051 @default.
• W2052398791 cites W1977813572 @default.
• W2052398791 cites W1984870257 @default.
• W2052398791 cites W1989833559 @default.
• W2052398791 cites W1990752558 @default.
• W2052398791 cites W1996589674 @default.
• W2052398791 cites W199661143 @default.
• W2052398791 cites W1997913988 @default.
• W2052398791 cites W1999843368 @default.
• W2052398791 cites W2002896646 @default.
• W2052398791 cites W2003506751 @default.
• W2052398791 cites W2016779336 @default.
• W2052398791 cites W2019690226 @default.
• W2052398791 cites W2024876976 @default.
• W2052398791 cites W2028320321 @default.
• W2052398791 cites W2036362108 @default.
• W2052398791 cites W2042447398 @default.
• W2052398791 cites W2052742260 @default.
• W2052398791 cites W2056313099 @default.
• W2052398791 cites W2058059121 @default.
• W2052398791 cites W2061378782 @default.
• W2052398791 cites W2061679676 @default.
• W2052398791 cites W2064958479 @default.
• W2052398791 cites W2065065003 @default.
• W2052398791 cites W2066419715 @default.
• W2052398791 cites W2069638209 @default.
• W2052398791 cites W2090271811 @default.
• W2052398791 cites W2091924214 @default.
• W2052398791 cites W2092925080 @default.
• W2052398791 cites W2094869059 @default.
• W2052398791 cites W2097608504 @default.
• W2052398791 cites W2104159099 @default.
• W2052398791 cites W2114729479 @default.
• W2052398791 cites W2116866168 @default.
• W2052398791 cites W2137755029 @default.
• W2052398791 cites W2146729934 @default.
• W2052398791 cites W2147369159 @default.
• W2052398791 cites W2149497936 @default.
• W2052398791 cites W2155534256 @default.
• W2052398791 cites W2156275187 @default.
• W2052398791 cites W2156326104 @default.
• W2052398791 cites W2156496314 @default.
• W2052398791 cites W2163462038 @default.
• W2052398791 cites W2170069716 @default.
• W2052398791 cites W2414941237 @default.
• W2052398791 cites W2416641863 @default.
• W2052398791 cites W2421536777 @default.
• W2052398791 cites W346391593 @default.
• W2052398791 cites W4213387068 @default.
• W2052398791 doi "https://doi.org/10.1016/j.mcn.2007.06.009" @default.
• W2052398791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3625967" @default.
• W2052398791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17822919" @default.
• W2052398791 hasPublicationYear "2007" @default.
• W2052398791 type Work @default.
• W2052398791 sameAs 2052398791 @default.
• W2052398791 citedByCount "40" @default.
• W2052398791 countsByYear W20523987912012 @default.
• W2052398791 countsByYear W20523987912013 @default.
• W2052398791 countsByYear W20523987912014 @default.
• W2052398791 countsByYear W20523987912016 @default.
• W2052398791 countsByYear W20523987912017 @default.
• W2052398791 countsByYear W20523987912018 @default.
• W2052398791 countsByYear W20523987912019 @default.
• W2052398791 countsByYear W20523987912020 @default.
• W2052398791 countsByYear W20523987912021 @default.
• W2052398791 countsByYear W20523987912022 @default.
• W2052398791 countsByYear W20523987912023 @default.
• W2052398791 crossrefType "journal-article" @default.
• W2052398791 hasAuthorship W2052398791A5000687935 @default.
• W2052398791 hasAuthorship W2052398791A5014103338 @default.
• W2052398791 hasAuthorship W2052398791A5017204895 @default.
• W2052398791 hasAuthorship W2052398791A5020266650 @default.
• W2052398791 hasAuthorship W2052398791A5031025675 @default.
• W2052398791 hasAuthorship W2052398791A5035618662 @default.
• W2052398791 hasAuthorship W2052398791A5043275152 @default.
• W2052398791 hasAuthorship W2052398791A5044048238 @default.

• next