FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052407739> ?p ?o ?g. }

• W2052407739 endingPage "423" @default.
• W2052407739 startingPage "413" @default.
• W2052407739 abstract "To determine the role of microRNA 21(miR-21) on left ventricular remodeling of rat heart with ischemia-reperfusion (I/R) injury and to investigate the underlying mechanism of miR-21 mediated myocardium protection.Rats were randomly divided into three groups: an I/R model group with Ad-GFP (Ad-GFP group), an I/R model group with Ad-miR-21 (Ad-miR-21 group) and a sham-surgery group. Changes in hemodynamic parameters were recorded at 1 week after I/R. Histological diagnosis was achieved by hematoxylin and eosin (H&E). Left ventricular (LV) dimensions, myocardial infarct size, LV/BW, collagen type Ⅰ, type Ⅲ and PCNA positive cells were measured. Primary cultures of neonatal rat cardiac ventricular myocytes were performed and cell ischemic injury was induced by hypoxia in a serum- and glucose-free medium, and reoxygenation (H/R). MiR-21 inhibitor and pre-miR-21 were respectively added to the culture medium for the miR-21 knockdown and for the miR-21 up-regulation. qRT-PCR was used to determine the miR-21 levels in cultured cells. Flow cytometry was performed to examine the cell apoptosis.In the Ad-miR-21 group, LV dimensions, myocardial infarct size, LV/BW, collagen type Ⅰ, type Ⅲ and PCNA positive cells all significantly decreased compared with the Ad-GFP group. At 1 week after I/R, the Ad-miR-21 significantly improved LVSP, LV +dp/dt(max), LV - dp/dt(min), and decreased heart rate (HR) and LVEDP compared with the Ad-GFP group. Compared with the Ad-GFP, the cell apoptotic rate significantly decreased in the Ad-miR-21 group. The miR-21 inhibitor exacerbated cardiac myocyte apoptosis and the pre-miR-21 decreased hypoxia/reoxygenation- induced cardiac myocyte apoptosis.Ad-miR-21 improves LV remodeling and decreases the apoptosis of myocardial cells, suggesting the possible mechanism by which Ad-miR-21 functions in protecting against I/R injury." @default.
• W2052407739 created "2016-06-24" @default.
• W2052407739 creator A5001128224 @default.
• W2052407739 creator A5005091420 @default.
• W2052407739 creator A5013761644 @default.
• W2052407739 creator A5020227451 @default.
• W2052407739 creator A5033302128 @default.
• W2052407739 creator A5075184660 @default.
• W2052407739 date "2012-01-01" @default.
• W2052407739 modified "2023-10-14" @default.
• W2052407739 title "MicroRNA 21 Inhibits Left Ventricular Remodeling in the Early Phase of Rat Model with Ischemia-reperfusion Injury by Suppressing Cell Apoptosis" @default.
• W2052407739 cites W1961356611 @default.
• W2052407739 cites W1963640511 @default.
• W2052407739 cites W1976129366 @default.
• W2052407739 cites W1988083024 @default.
• W2052407739 cites W1990868443 @default.
• W2052407739 cites W2016964783 @default.
• W2052407739 cites W2024759036 @default.
• W2052407739 cites W2027485242 @default.
• W2052407739 cites W2031203524 @default.
• W2052407739 cites W2038696333 @default.
• W2052407739 cites W2055416829 @default.
• W2052407739 cites W2060072724 @default.
• W2052407739 cites W2066451181 @default.
• W2052407739 cites W2078532650 @default.
• W2052407739 cites W2080808874 @default.
• W2052407739 cites W2083381199 @default.
• W2052407739 cites W2086809547 @default.
• W2052407739 cites W2096166765 @default.
• W2052407739 cites W2097837136 @default.
• W2052407739 cites W2103211592 @default.
• W2052407739 cites W2104610341 @default.
• W2052407739 cites W2107033535 @default.
• W2052407739 cites W2121236121 @default.
• W2052407739 cites W2123471730 @default.
• W2052407739 cites W2124268899 @default.
• W2052407739 cites W2129882693 @default.
• W2052407739 cites W2132093971 @default.
• W2052407739 cites W2141570739 @default.
• W2052407739 cites W2150037286 @default.
• W2052407739 cites W2156554003 @default.
• W2052407739 cites W2156822822 @default.
• W2052407739 cites W2165764599 @default.
• W2052407739 cites W2167650832 @default.
• W2052407739 cites W2169910516 @default.
• W2052407739 cites W2341478304 @default.
• W2052407739 cites W76973823 @default.
• W2052407739 doi "https://doi.org/10.7150/ijms.4514" @default.
• W2052407739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3410360" @default.
• W2052407739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22859901" @default.
• W2052407739 hasPublicationYear "2012" @default.
• W2052407739 type Work @default.
• W2052407739 sameAs 2052407739 @default.
• W2052407739 citedByCount "78" @default.
• W2052407739 countsByYear W20524077392013 @default.
• W2052407739 countsByYear W20524077392014 @default.
• W2052407739 countsByYear W20524077392015 @default.
• W2052407739 countsByYear W20524077392016 @default.
• W2052407739 countsByYear W20524077392017 @default.
• W2052407739 countsByYear W20524077392018 @default.
• W2052407739 countsByYear W20524077392019 @default.
• W2052407739 countsByYear W20524077392020 @default.
• W2052407739 countsByYear W20524077392021 @default.
• W2052407739 countsByYear W20524077392022 @default.
• W2052407739 countsByYear W20524077392023 @default.
• W2052407739 crossrefType "journal-article" @default.
• W2052407739 hasAuthorship W2052407739A5001128224 @default.
• W2052407739 hasAuthorship W2052407739A5005091420 @default.
• W2052407739 hasAuthorship W2052407739A5013761644 @default.
• W2052407739 hasAuthorship W2052407739A5020227451 @default.
• W2052407739 hasAuthorship W2052407739A5033302128 @default.
• W2052407739 hasAuthorship W2052407739A5075184660 @default.
• W2052407739 hasBestOaLocation W20524077391 @default.
• W2052407739 hasConcept C125473707 @default.
• W2052407739 hasConcept C126322002 @default.
• W2052407739 hasConcept C134018914 @default.
• W2052407739 hasConcept C164705383 @default.
• W2052407739 hasConcept C16685009 @default.
• W2052407739 hasConcept C173396325 @default.
• W2052407739 hasConcept C178853913 @default.
• W2052407739 hasConcept C185592680 @default.
• W2052407739 hasConcept C190283241 @default.
• W2052407739 hasConcept C203014093 @default.
• W2052407739 hasConcept C204232928 @default.
• W2052407739 hasConcept C207200792 @default.
• W2052407739 hasConcept C2779537366 @default.
• W2052407739 hasConcept C2780114680 @default.
• W2052407739 hasConcept C34688535 @default.
• W2052407739 hasConcept C48277249 @default.
• W2052407739 hasConcept C500558357 @default.
• W2052407739 hasConcept C541997718 @default.
• W2052407739 hasConcept C553184892 @default.
• W2052407739 hasConcept C55493867 @default.
• W2052407739 hasConcept C71924100 @default.
• W2052407739 hasConceptScore W2052407739C125473707 @default.
• W2052407739 hasConceptScore W2052407739C126322002 @default.
• W2052407739 hasConceptScore W2052407739C134018914 @default.
• W2052407739 hasConceptScore W2052407739C164705383 @default.

• next