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- W2052427467 startingPage "17" @default.
- W2052427467 abstract "5β-Reduced steroids are non-planar steroids that have a 90° bend in their structure to create an A/B cis-ring junction. This novel property is required for bile-acids to act as emulsifiers, but in addition 5β-reduced steroids have remarkable physiology and may act as potent tocolytic agents, endogenous cardiac glycosides, neurosteroids, and can act as ligands for orphan and membrane bound receptors. In humans there is only a single 5β-reductase gene AKR1D1, which encodes Δ4-3-ketosteroid-5β-reductase (AKR1D1). This enzyme is a member of the aldo–keto reductase superfamily, but possesses an altered catalytic tetrad, in which Glu120 replaces the conserved His residue. This predominant liver enzyme generates all 5β-dihydrosteroids in the C19–C27 steroid series. Mutations exist in the AKR1D1 gene, which result in loss of protein stability and are causative in bile-acid deficiency." @default.
- W2052427467 created "2016-06-24" @default.
- W2052427467 creator A5043858190 @default.
- W2052427467 creator A5059737908 @default.
- W2052427467 date "2014-05-01" @default.
- W2052427467 modified "2023-10-17" @default.
- W2052427467 title "5β-Reduced steroids and human Δ4-3-ketosteroid 5β-reductase (AKR1D1)" @default.
- W2052427467 cites W1541228389 @default.
- W2052427467 cites W1557438712 @default.
- W2052427467 cites W1564906832 @default.
- W2052427467 cites W1576975040 @default.
- W2052427467 cites W1611445504 @default.
- W2052427467 cites W1770562442 @default.
- W2052427467 cites W1957435031 @default.
- W2052427467 cites W1964287283 @default.
- W2052427467 cites W1966922165 @default.
- W2052427467 cites W1967383598 @default.
- W2052427467 cites W1967411579 @default.
- W2052427467 cites W1970465623 @default.
- W2052427467 cites W1971183665 @default.
- W2052427467 cites W1971511316 @default.
- W2052427467 cites W1971823316 @default.
- W2052427467 cites W1974616640 @default.
- W2052427467 cites W1975129786 @default.
- W2052427467 cites W1981242139 @default.
- W2052427467 cites W1981769262 @default.
- W2052427467 cites W1982056201 @default.
- W2052427467 cites W1982478930 @default.
- W2052427467 cites W1984687894 @default.
- W2052427467 cites W1985145085 @default.
- W2052427467 cites W1985481419 @default.
- W2052427467 cites W1987534461 @default.
- W2052427467 cites W1989048171 @default.
- W2052427467 cites W1991639177 @default.
- W2052427467 cites W1991975419 @default.
- W2052427467 cites W1992013033 @default.
- W2052427467 cites W1992050943 @default.
- W2052427467 cites W1994305925 @default.
- W2052427467 cites W1994904927 @default.
- W2052427467 cites W1996613222 @default.
- W2052427467 cites W1996799615 @default.
- W2052427467 cites W1999990292 @default.
- W2052427467 cites W2000204672 @default.
- W2052427467 cites W2002525411 @default.
- W2052427467 cites W2003170183 @default.
- W2052427467 cites W2003501217 @default.
- W2052427467 cites W2003631076 @default.
- W2052427467 cites W2004853397 @default.
- W2052427467 cites W2005216358 @default.
- W2052427467 cites W2005732363 @default.
- W2052427467 cites W2008355987 @default.
- W2052427467 cites W2009582193 @default.
- W2052427467 cites W2012352047 @default.
- W2052427467 cites W2017362076 @default.
- W2052427467 cites W2019349841 @default.
- W2052427467 cites W2020121378 @default.
- W2052427467 cites W2021206718 @default.
- W2052427467 cites W2021444563 @default.
- W2052427467 cites W2024406042 @default.
- W2052427467 cites W2024727512 @default.
- W2052427467 cites W2025202132 @default.
- W2052427467 cites W2026621866 @default.
- W2052427467 cites W2028166730 @default.
- W2052427467 cites W2034446966 @default.
- W2052427467 cites W2035575075 @default.
- W2052427467 cites W2036004493 @default.
- W2052427467 cites W2037321425 @default.
- W2052427467 cites W2042947181 @default.
- W2052427467 cites W2052179888 @default.
- W2052427467 cites W2052801326 @default.
- W2052427467 cites W2053833972 @default.
- W2052427467 cites W2055252534 @default.
- W2052427467 cites W2056794732 @default.
- W2052427467 cites W2060603106 @default.
- W2052427467 cites W2061064556 @default.
- W2052427467 cites W2064449254 @default.
- W2052427467 cites W2065051999 @default.
- W2052427467 cites W2069595524 @default.
- W2052427467 cites W2069962157 @default.
- W2052427467 cites W2070798440 @default.
- W2052427467 cites W2070885472 @default.
- W2052427467 cites W2071273298 @default.
- W2052427467 cites W2075145938 @default.
- W2052427467 cites W2076667785 @default.
- W2052427467 cites W2080578796 @default.
- W2052427467 cites W2081028309 @default.
- W2052427467 cites W2087577664 @default.
- W2052427467 cites W2089220629 @default.
- W2052427467 cites W2091953759 @default.
- W2052427467 cites W2094065901 @default.
- W2052427467 cites W2094388193 @default.
- W2052427467 cites W2094678200 @default.
- W2052427467 cites W2094699302 @default.
- W2052427467 cites W2096418655 @default.
- W2052427467 cites W2099081805 @default.
- W2052427467 cites W2099467426 @default.
- W2052427467 cites W2104181407 @default.
- W2052427467 cites W2104895456 @default.