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- W2052441965 abstract "Because of the reported uneven vascular distribution of the enzyme, angiotensin converting enzyme (ACE), we hypothesized that the magnitude of blood pressure responses to bolus injections of angiotensin I (Ang I) and bradykinin (BK) would be dependent upon the route of administration, i.e., intra-arterial (i.a.) or intra-venous (i.v.). Anesthetized rats with cannulas in the left carotid artery and the right internal jugular vein were given bolus injections of each agent, alternating between the two cannulas. Intra-venous injections of Ang I produced transient increases in arterial pressure that were significantly greater (27 +/- 12%) and longer (7 +/- 7%) than those induced by equimolar i.a. injections within the same preparation. Intra-venous injections of BK produced transient decreases in arterial pressure that were significantly smaller (72 +/- 4%) and shorter (78 +/- 11%) than similar i.a. injections. Unexpectedly, i.v. injections of Ang II also evoked slightly larger transient increases in arterial pressure (11 +/- 4%) than similar i.a. injections. These results suggest that enzymatic alterations of Ang I and BK probably by angiotensin converting enzyme during their initial passage through the pulmonary circulation has a small but significant influence on their pressor effects." @default.
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- W2052441965 date "1998-01-01" @default.
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- W2052441965 title "Comparison of blood pressure responses to intra-arterial and intra-vendus injections of angiotensin I, angiotensin II and bradykinin" @default.
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- W2052441965 doi "https://doi.org/10.1016/s0024-3205(97)01189-2" @default.
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