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• W2052445668 abstract "A growing body of evidence suggests the involvement of brain-derived neurotrophic factor (BDNF) in both antipsychotic action and schizophrenia pathogenesis. The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with schizophrenia and clozapine's therapeutic response. To identify any genetic predisposition to schizophrenia, we studied the BDNF-gene Val66Met polymorphism in 93 schizophrenic patients and 198 normal controls. Statistical analysis was used to test the association between this polymorphism and clozapine response the schizophrenic group. A trend (P=0.055) was demonstrated between genetic predisposition and Val66Met genotypes in 93 schizophrenic patients, especially for those with good response to clozapine (P=0.023). No significant difference in clozapine therapeutic response was demonstrated comparing the three Val66Met-genotype subgroups. Our finding suggests that this BDNF-gene Val66Met polymorphism may be related to schizophrenia pathogenesis in patients responsive to clozapine treatment." @default.
• W2052445668 created "2016-06-24" @default.
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• W2052445668 date "2003-10-01" @default.
• W2052445668 modified "2023-10-16" @default.
• W2052445668 title "An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients" @default.
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• W2052445668 doi "https://doi.org/10.1016/s0304-3940(03)00828-0" @default.
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