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• W2052451750 abstract "OBJECTIVE: We used the premature rabbit model of surfactant deficiency to test the hypothesis that perinatal administration of terbutaline would lead to increased secretion of surfactant into the alveolar space and increase lung compliance during mechanical ventilation. STUDY DESIGN: Fetuses underwent delivery at a gestational age of 28 days (term 31 days) followed by mechanical ventilation. Fetuses were subdivided into four treatment protocols: control, fetuses given terbutaline at birth, fetuses of mothers given terbutaline 1 hour before delivery, and fetuses of mothers given terbutaline intramuscularly 12 hours before delivery. Dynamic compliance was determined. After this, alveolar lavage fluid was obtained for phosphatidylcholine content determination. Some fetuses were killed at birth and their alveolar lavage phosphatidylcholine was determined. RESULTS: Among the fetuses undergoing mechanical ventilation, perinatal terbutaline exposure did not alter either dynamic compliance or alveolar lavage phosphatidylcholine. Mechanical ventilaton was associated with large increases in alveolar lavage phosphatidylcholine content. CONCLUSION: Perinatal β-adrenergic agonist exposure does not alter in vivo lung function following preterm delivery. OBJECTIVE: We used the premature rabbit model of surfactant deficiency to test the hypothesis that perinatal administration of terbutaline would lead to increased secretion of surfactant into the alveolar space and increase lung compliance during mechanical ventilation. STUDY DESIGN: Fetuses underwent delivery at a gestational age of 28 days (term 31 days) followed by mechanical ventilation. Fetuses were subdivided into four treatment protocols: control, fetuses given terbutaline at birth, fetuses of mothers given terbutaline 1 hour before delivery, and fetuses of mothers given terbutaline intramuscularly 12 hours before delivery. Dynamic compliance was determined. After this, alveolar lavage fluid was obtained for phosphatidylcholine content determination. Some fetuses were killed at birth and their alveolar lavage phosphatidylcholine was determined. RESULTS: Among the fetuses undergoing mechanical ventilation, perinatal terbutaline exposure did not alter either dynamic compliance or alveolar lavage phosphatidylcholine. Mechanical ventilaton was associated with large increases in alveolar lavage phosphatidylcholine content. CONCLUSION: Perinatal β-adrenergic agonist exposure does not alter in vivo lung function following preterm delivery." @default.
• W2052451750 created "2016-06-24" @default.
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• W2052451750 date "1992-09-01" @default.
• W2052451750 modified "2023-09-27" @default.
• W2052451750 title "Terbutaline does not improve lung function in preterm rabbits" @default.
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• W2052451750 doi "https://doi.org/10.1016/s0002-9378(11)91600-7" @default.
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