Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052455532> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2052455532 endingPage "2203" @default.
- W2052455532 startingPage "2195" @default.
- W2052455532 abstract "Insulin responses to nutrient secretagogues were investigated in neonatally streptozotocin-injected (n-STZ) rats, i.e. an animal model of noninsulin-dependent diabetes. In the perfused pancreas 16 mM L-glutamine induced and 10 mM octanoate tended to induce (P less than 0.2) higher responses in n-STZ than in nondiabetic rats. Addition of 3.9 mM glucose potentiated responses to glutamine and octanoate more in n-STZ (3.3- and 3.4-fold) than in nondiabetic rats (1.5- and 1.9-fold). Conversely, the succinate derivative succinate monomethylester (Succ ME) induced lesser response in n-STZ rats (57% of that in nondiabetic rats) and coperfusion with 3.9 mM glucose increased the response less in n-STZ (1.4-fold) than in nondiabetic rats (3.8-fold). Pyruvate (20 mM) mimicked the potency of 3.9 mM glucose, i.e. pyruvate potentiated the response to Succ ME only nonsignificantly (1.2-fold) in n-STZ but markedly (4.9-fold) in nondiabetic rats. Dichloroacetate (20 mM) failed to affect the response to Succ ME together with pyruvate in n-STZ rats. To investigate the role of hyperglycemia for octanoate-induced secretion, nondiabetic rats were made hyperglycemic by 48-h glucose infusions. Octanoate-induced secretion from perfused pancreas was enhanced 3.8-fold after moderate hyperglycemia (13.2 +/- 0.6 mM) and 17-fold after marked hyperglycemia (22.7 +/- 0.6 mM). This positive association between response and degree of hyperglycemia was not found with a nonnutrient secretagogue, 3-isobutyl-1-methylxanthine. Results with glutamine and octanoate indicate that oxidation of nonglucose nutrients which normally do not regulate secretion is enhanced secondary to chronic hyperglycemia. Results with Succ ME and pyruvate suggest that early steps of oxidation of glucose are impaired in n-STZ rats." @default.
- W2052455532 created "2016-06-24" @default.
- W2052455532 creator A5003637007 @default.
- W2052455532 creator A5017522902 @default.
- W2052455532 creator A5046746449 @default.
- W2052455532 creator A5090090811 @default.
- W2052455532 date "1991-04-01" @default.
- W2052455532 modified "2023-10-16" @default.
- W2052455532 title "Multiple Abnormalities in Insulin Responses to Nonglucose Nutrients in Neonatally Streptozotocin Diabetic Rats*" @default.
- W2052455532 cites W1500111450 @default.
- W2052455532 cites W1507372364 @default.
- W2052455532 cites W1940095969 @default.
- W2052455532 cites W1975902039 @default.
- W2052455532 cites W1979865085 @default.
- W2052455532 cites W1986538307 @default.
- W2052455532 cites W1986624609 @default.
- W2052455532 cites W1997114752 @default.
- W2052455532 cites W2011508827 @default.
- W2052455532 cites W2019438325 @default.
- W2052455532 cites W2020346541 @default.
- W2052455532 cites W2042203830 @default.
- W2052455532 cites W2069827981 @default.
- W2052455532 cites W2078073869 @default.
- W2052455532 cites W20780901 @default.
- W2052455532 cites W2078176355 @default.
- W2052455532 cites W2079012777 @default.
- W2052455532 cites W2079112323 @default.
- W2052455532 cites W2079717789 @default.
- W2052455532 cites W2088055031 @default.
- W2052455532 cites W2088991722 @default.
- W2052455532 cites W2100624249 @default.
- W2052455532 cites W2130517230 @default.
- W2052455532 cites W2133385625 @default.
- W2052455532 cites W2153347819 @default.
- W2052455532 cites W2157604930 @default.
- W2052455532 cites W2318009091 @default.
- W2052455532 cites W2466994925 @default.
- W2052455532 doi "https://doi.org/10.1210/endo-128-4-2195" @default.
- W2052455532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1706269" @default.
- W2052455532 hasPublicationYear "1991" @default.
- W2052455532 type Work @default.
- W2052455532 sameAs 2052455532 @default.
- W2052455532 citedByCount "8" @default.
- W2052455532 crossrefType "journal-article" @default.
- W2052455532 hasAuthorship W2052455532A5003637007 @default.
- W2052455532 hasAuthorship W2052455532A5017522902 @default.
- W2052455532 hasAuthorship W2052455532A5046746449 @default.
- W2052455532 hasAuthorship W2052455532A5090090811 @default.
- W2052455532 hasConcept C126322002 @default.
- W2052455532 hasConcept C134018914 @default.
- W2052455532 hasConcept C185592680 @default.
- W2052455532 hasConcept C202751555 @default.
- W2052455532 hasConcept C2779280383 @default.
- W2052455532 hasConcept C2779306644 @default.
- W2052455532 hasConcept C2779349466 @default.
- W2052455532 hasConcept C2780161494 @default.
- W2052455532 hasConcept C515207424 @default.
- W2052455532 hasConcept C55493867 @default.
- W2052455532 hasConcept C555293320 @default.
- W2052455532 hasConcept C57992300 @default.
- W2052455532 hasConcept C71924100 @default.
- W2052455532 hasConceptScore W2052455532C126322002 @default.
- W2052455532 hasConceptScore W2052455532C134018914 @default.
- W2052455532 hasConceptScore W2052455532C185592680 @default.
- W2052455532 hasConceptScore W2052455532C202751555 @default.
- W2052455532 hasConceptScore W2052455532C2779280383 @default.
- W2052455532 hasConceptScore W2052455532C2779306644 @default.
- W2052455532 hasConceptScore W2052455532C2779349466 @default.
- W2052455532 hasConceptScore W2052455532C2780161494 @default.
- W2052455532 hasConceptScore W2052455532C515207424 @default.
- W2052455532 hasConceptScore W2052455532C55493867 @default.
- W2052455532 hasConceptScore W2052455532C555293320 @default.
- W2052455532 hasConceptScore W2052455532C57992300 @default.
- W2052455532 hasConceptScore W2052455532C71924100 @default.
- W2052455532 hasIssue "4" @default.
- W2052455532 hasLocation W20524555321 @default.
- W2052455532 hasLocation W20524555322 @default.
- W2052455532 hasOpenAccess W2052455532 @default.
- W2052455532 hasPrimaryLocation W20524555321 @default.
- W2052455532 hasRelatedWork W1976841804 @default.
- W2052455532 hasRelatedWork W2003485540 @default.
- W2052455532 hasRelatedWork W2023960546 @default.
- W2052455532 hasRelatedWork W2052455532 @default.
- W2052455532 hasRelatedWork W2079809161 @default.
- W2052455532 hasRelatedWork W2094002640 @default.
- W2052455532 hasRelatedWork W2110028249 @default.
- W2052455532 hasRelatedWork W2400635381 @default.
- W2052455532 hasRelatedWork W2434287781 @default.
- W2052455532 hasRelatedWork W4240404135 @default.
- W2052455532 hasVolume "128" @default.
- W2052455532 isParatext "false" @default.
- W2052455532 isRetracted "false" @default.
- W2052455532 magId "2052455532" @default.
- W2052455532 workType "article" @default.