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• W2052465649 abstract "Summary A study has been conducted of the in vivo tissue distribution of intravenously administered C 14 -labeled cholesterol and triglyceride (Lipomul) preparations in Wistar rats and of the in vitro binding capacities of native and aldehyde-crosslinked bovine aortas and aortic elastin preparations for these materials. The data suggest: (a) that normal aortic wall cells are active phagocytic components of the reticuloendothelial system (RES) in vivo; (b) that recirculation of C 14 -labeled lipid macromolecules occurs with time, resulting in a transfer of label from liver and spleen depots to, primarily, the aorta and lung; (c) that the in vitro binding capacity of the aortic wall for either Lipomul or cholesterol is not significantly altered by the introduction of aldehyde-mediated crosslinkages; and (d) that the major portion of the observed in vitro adsorption represents physical adsorption (and not true chemical bonding) to both elastin and other constituents of the aortic wall. It is postulated that the occurrence of agedependent or “pathologic” crosslinkages in aortic wall protein chains is manifested essentially by changes in the mechanical properties of the wall as a structural (“fabric”) material, and that these are associated in vivo with alterations in the surface properties of the intima and/or in intraluminal blood flow patterns such that pinocytosis of circulating lipid macromolecules by normally phagocytic intimal cells can be significantly increased." @default.
• W2052465649 created "2016-06-24" @default.
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• W2052465649 date "1965-09-01" @default.
• W2052465649 modified "2023-09-26" @default.
• W2052465649 title "Aortic distribution and binding of C14-labeled cholesterol and lipomul by native rat aortas and aldehyde-crosslinked bovine aortas" @default.
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• W2052465649 doi "https://doi.org/10.1016/s0022-4804(65)80035-x" @default.
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