FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052471444> ?p ?o ?g. }

• W2052471444 endingPage "2297" @default.
• W2052471444 startingPage "2293" @default.
• W2052471444 abstract "Patients diagnosed with advanced gastrointestinal stromal tumours (GISTs) who are resistant or intolerant to both imatinib and second-line sunitinib have a poor prognosis and few therapeutic options. We evaluated the efficacy of nilotinib, a novel tyrosine kinase inhibitor (TKI) in patients pretreated with imatinib and sunitinib. Fifty-two consecutive patients treated with oral nilotinib, 400 mg twice daily, within the nilotinib compassionate use programme in 12 European cancer centres, were included in this retrospective analysis. Median age was 59 years (range 24–80), and all patients had WHO performance score better than 3. All patients had failed both imatinib and sunitinib pretreatment, either due to progressing GIST (96%) or intolerance (4%). Five patients (10%; 95% confidence interval (CI) 2–18) responded to nilotinib and 19 patients (37%; 95% CI 24–50) achieved a disease stabilisation. Nilotinib was generally well tolerated, but six patients (12%) discontinued treatment due to intolerance. Median progression-free survival of nilotinib treatment was 12 weeks (95% CI 9–15; range 0–104) and median overall survival was 34 weeks (95% CI 3–65; range 2–135). Nilotinib is active in GIST resistant to both imatinib and sunitinib. These results warrant further investigation of nilotinib in GIST." @default.
• W2052471444 created "2016-06-24" @default.
• W2052471444 creator A5001987856 @default.
• W2052471444 creator A5006933759 @default.
• W2052471444 creator A5010184874 @default.
• W2052471444 creator A5012453950 @default.
• W2052471444 creator A5021550191 @default.
• W2052471444 creator A5025804381 @default.
• W2052471444 creator A5025935523 @default.
• W2052471444 creator A5031165822 @default.
• W2052471444 creator A5039207289 @default.
• W2052471444 creator A5046968710 @default.
• W2052471444 creator A5048170384 @default.
• W2052471444 creator A5053741452 @default.
• W2052471444 creator A5064487920 @default.
• W2052471444 creator A5090618504 @default.
• W2052471444 date "2009-09-01" @default.
• W2052471444 modified "2023-10-14" @default.
• W2052471444 title "Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib" @default.
• W2052471444 cites W1981491302 @default.
• W2052471444 cites W1987005540 @default.
• W2052471444 cites W2008920989 @default.
• W2052471444 cites W2010415450 @default.
• W2052471444 cites W2011324997 @default.
• W2052471444 cites W2057718276 @default.
• W2052471444 cites W2066099870 @default.
• W2052471444 cites W2115504770 @default.
• W2052471444 cites W2116441743 @default.
• W2052471444 cites W2124196948 @default.
• W2052471444 cites W2129931005 @default.
• W2052471444 cites W2130105793 @default.
• W2052471444 cites W2139248078 @default.
• W2052471444 cites W2139511378 @default.
• W2052471444 cites W2150501295 @default.
• W2052471444 cites W2156669735 @default.
• W2052471444 cites W2160215400 @default.
• W2052471444 cites W2169363650 @default.
• W2052471444 cites W2171620774 @default.
• W2052471444 cites W2314511842 @default.
• W2052471444 cites W2324850882 @default.
• W2052471444 cites W2502318046 @default.
• W2052471444 cites W2795801398 @default.
• W2052471444 cites W3041047318 @default.
• W2052471444 doi "https://doi.org/10.1016/j.ejca.2009.04.030" @default.
• W2052471444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19467857" @default.
• W2052471444 hasPublicationYear "2009" @default.
• W2052471444 type Work @default.
• W2052471444 sameAs 2052471444 @default.
• W2052471444 citedByCount "133" @default.
• W2052471444 countsByYear W20524714442012 @default.
• W2052471444 countsByYear W20524714442013 @default.
• W2052471444 countsByYear W20524714442014 @default.
• W2052471444 countsByYear W20524714442015 @default.
• W2052471444 countsByYear W20524714442016 @default.
• W2052471444 countsByYear W20524714442017 @default.
• W2052471444 countsByYear W20524714442018 @default.
• W2052471444 countsByYear W20524714442019 @default.
• W2052471444 countsByYear W20524714442020 @default.
• W2052471444 countsByYear W20524714442021 @default.
• W2052471444 countsByYear W20524714442022 @default.
• W2052471444 countsByYear W20524714442023 @default.
• W2052471444 crossrefType "journal-article" @default.
• W2052471444 hasAuthorship W2052471444A5001987856 @default.
• W2052471444 hasAuthorship W2052471444A5006933759 @default.
• W2052471444 hasAuthorship W2052471444A5010184874 @default.
• W2052471444 hasAuthorship W2052471444A5012453950 @default.
• W2052471444 hasAuthorship W2052471444A5021550191 @default.
• W2052471444 hasAuthorship W2052471444A5025804381 @default.
• W2052471444 hasAuthorship W2052471444A5025935523 @default.
• W2052471444 hasAuthorship W2052471444A5031165822 @default.
• W2052471444 hasAuthorship W2052471444A5039207289 @default.
• W2052471444 hasAuthorship W2052471444A5046968710 @default.
• W2052471444 hasAuthorship W2052471444A5048170384 @default.
• W2052471444 hasAuthorship W2052471444A5053741452 @default.
• W2052471444 hasAuthorship W2052471444A5064487920 @default.
• W2052471444 hasAuthorship W2052471444A5090618504 @default.
• W2052471444 hasConcept C121608353 @default.
• W2052471444 hasConcept C126322002 @default.
• W2052471444 hasConcept C141071460 @default.
• W2052471444 hasConcept C143998085 @default.
• W2052471444 hasConcept C16930146 @default.
• W2052471444 hasConcept C2775922572 @default.
• W2052471444 hasConcept C2777413986 @default.
• W2052471444 hasConcept C2777583451 @default.
• W2052471444 hasConcept C2778729363 @default.
• W2052471444 hasConcept C2778820342 @default.
• W2052471444 hasConcept C2779490328 @default.
• W2052471444 hasConcept C3019892230 @default.
• W2052471444 hasConcept C71924100 @default.
• W2052471444 hasConcept C90924648 @default.
• W2052471444 hasConceptScore W2052471444C121608353 @default.
• W2052471444 hasConceptScore W2052471444C126322002 @default.
• W2052471444 hasConceptScore W2052471444C141071460 @default.
• W2052471444 hasConceptScore W2052471444C143998085 @default.
• W2052471444 hasConceptScore W2052471444C16930146 @default.
• W2052471444 hasConceptScore W2052471444C2775922572 @default.
• W2052471444 hasConceptScore W2052471444C2777413986 @default.
• W2052471444 hasConceptScore W2052471444C2777583451 @default.

• next