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- W2052474562 abstract "Abstract The concept of using viruses to kill tumors has long been established, but the field has suffered great setbacks and “bottle neck” in target efficiency. The problem with using systemic virotherapy is that the immune system and tumor microenvironment could seek, sabotage and destroy virus, which allows only a tiny fraction of viruses to find their way to tumors. In our prospect, cytokine-induced killer (CIK) cells can be a prospective sheltering agent. The tumor-selective viruses encapsuled in CIK cells can be safely and efficiently delivered to tumor cells, attaining a synergy of tumor killing by both CIK cells and tumor-selective viruses. For successful delivery, the viruses should have high infectious ability to CIK cells, and the replication of viruses should be strictly modulated by cell vehicles. Ad5F35 chimeric adenovirus can be satisfactory agents if their replication can be driven by promoter of CD40 ligands. Moreover, ensuring absolute safety, either CIK cells or viral passengers can be engineered to express certain therapeutic genes to further enhance tumoricidal effect." @default.
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- W2052474562 date "2008-01-01" @default.
- W2052474562 modified "2023-10-16" @default.
- W2052474562 title "Cytokine-induced killer cells: A prospective vector for effective smuggling of oncolytic virus to tumor cells" @default.
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- W2052474562 doi "https://doi.org/10.1016/j.bihy.2008.07.009" @default.
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