FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052481777> ?p ?o ?g. }

• W2052481777 endingPage "e43080" @default.
• W2052481777 startingPage "e43080" @default.
• W2052481777 abstract "Mycobacterium ulcerans, the causative agent of Buruli ulcer, is the third most common mycobacterial disease after tuberculosis and leprosy. The present treatment options are limited and emergence of treatment resistant isolates represents a serious concern and a need for better therapeutics. Conventional drug discovery methods are time consuming and labor-intensive. Unfortunately, the slow growing nature of M. ulcerans in experimental conditions is also a barrier for drug discovery and development. In contrast, recent advancements in complete genome sequencing, in combination with cheminformatics and computational biology, represent an attractive alternative approach for the identification of therapeutic candidates worthy of experimental research. A computational, comparative genomics workflow was defined for the identification of novel therapeutic candidates against M. ulcerans, with the aim that a selected target should be essential to the pathogen, and have no homology in the human host. Initially, a total of 424 genes were predicted as essential from the M. ulcerans genome, via homology searching of essential genome content from 20 different bacteria. Metabolic pathway analysis showed that the most essential genes are associated with carbohydrate and amino acid metabolism. Among these, 236 proteins were identified as non-host and essential, and could serve as potential drug and vaccine candidates. Several drug target prioritization parameters including druggability were also calculated. Enzymes from several pathways are discussed as potential drug targets, including those from cell wall synthesis, thiamine biosynthesis, protein biosynthesis, and histidine biosynthesis. It is expected that our data will facilitate selection of M. ulcerans proteins for successful entry into drug design pipelines." @default.
• W2052481777 created "2016-06-24" @default.
• W2052481777 creator A5061191302 @default.
• W2052481777 creator A5070974938 @default.
• W2052481777 creator A5073447955 @default.
• W2052481777 creator A5076498979 @default.
• W2052481777 date "2012-08-13" @default.
• W2052481777 modified "2023-10-16" @default.
• W2052481777 title "Comparative Genomics Analysis of Mycobacterium ulcerans for the Identification of Putative Essential Genes and Therapeutic Candidates" @default.
• W2052481777 cites W1504899110 @default.
• W2052481777 cites W1511433968 @default.
• W2052481777 cites W1516459493 @default.
• W2052481777 cites W1522260798 @default.
• W2052481777 cites W1549668447 @default.
• W2052481777 cites W1608392597 @default.
• W2052481777 cites W1916292452 @default.
• W2052481777 cites W1971961760 @default.
• W2052481777 cites W1977377333 @default.
• W2052481777 cites W1979876583 @default.
• W2052481777 cites W1982440567 @default.
• W2052481777 cites W1985924323 @default.
• W2052481777 cites W1986569138 @default.
• W2052481777 cites W1990869486 @default.
• W2052481777 cites W1993846180 @default.
• W2052481777 cites W1995405638 @default.
• W2052481777 cites W1995498227 @default.
• W2052481777 cites W1996612368 @default.
• W2052481777 cites W1998437697 @default.
• W2052481777 cites W1998498230 @default.
• W2052481777 cites W2005671213 @default.
• W2052481777 cites W2015776846 @default.
• W2052481777 cites W2018408116 @default.
• W2052481777 cites W2018590530 @default.
• W2052481777 cites W2022012591 @default.
• W2052481777 cites W2025538655 @default.
• W2052481777 cites W2031364460 @default.
• W2052481777 cites W2032917297 @default.
• W2052481777 cites W2034584620 @default.
• W2052481777 cites W2035610697 @default.
• W2052481777 cites W2036790151 @default.
• W2052481777 cites W2042714420 @default.
• W2052481777 cites W2044350051 @default.
• W2052481777 cites W2052779789 @default.
• W2052481777 cites W2053574785 @default.
• W2052481777 cites W2054912906 @default.
• W2052481777 cites W2055624359 @default.
• W2052481777 cites W2057109942 @default.
• W2052481777 cites W2057717820 @default.
• W2052481777 cites W2059443843 @default.
• W2052481777 cites W2063899212 @default.
• W2052481777 cites W2066915800 @default.
• W2052481777 cites W2067471800 @default.
• W2052481777 cites W2067513135 @default.
• W2052481777 cites W2076952762 @default.
• W2052481777 cites W2082399236 @default.
• W2052481777 cites W2084865148 @default.
• W2052481777 cites W2086084754 @default.
• W2052481777 cites W2088590769 @default.
• W2052481777 cites W2088710021 @default.
• W2052481777 cites W2090728933 @default.
• W2052481777 cites W2091050184 @default.
• W2052481777 cites W2092044537 @default.
• W2052481777 cites W2092247420 @default.
• W2052481777 cites W2092369184 @default.
• W2052481777 cites W2099098590 @default.
• W2052481777 cites W2099651125 @default.
• W2052481777 cites W2103314455 @default.
• W2052481777 cites W2104600295 @default.
• W2052481777 cites W2105295234 @default.
• W2052481777 cites W2109670638 @default.
• W2052481777 cites W2114002561 @default.
• W2052481777 cites W2114993703 @default.
• W2052481777 cites W2115227691 @default.
• W2052481777 cites W2118408888 @default.
• W2052481777 cites W2121603293 @default.
• W2052481777 cites W2122349584 @default.
• W2052481777 cites W2128482141 @default.
• W2052481777 cites W2131736388 @default.
• W2052481777 cites W2137052779 @default.
• W2052481777 cites W2137319433 @default.
• W2052481777 cites W2140885472 @default.
• W2052481777 cites W2145723496 @default.
• W2052481777 cites W2148853951 @default.
• W2052481777 cites W2150006179 @default.
• W2052481777 cites W2150081979 @default.
• W2052481777 cites W2150744251 @default.
• W2052481777 cites W2152770371 @default.
• W2052481777 cites W2153872971 @default.
• W2052481777 cites W2158714788 @default.
• W2052481777 cites W2165634261 @default.
• W2052481777 cites W2165674132 @default.
• W2052481777 cites W2171437346 @default.
• W2052481777 cites W2184956732 @default.
• W2052481777 cites W2324604919 @default.
• W2052481777 cites W58618343 @default.
• W2052481777 doi "https://doi.org/10.1371/journal.pone.0043080" @default.
• W2052481777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3776887" @default.
• W2052481777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22912793" @default.

• next