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• W2052484041 abstract "PurposeOxcarbazepine (OXC) is a promising alternative for patients who cannot tolerate carbamazepine. Recently, however, it has been reported that OXC-induced cutaneous adverse drug reactions (cADRs) are prevalent and may lead to drug discontinuation. Additionally, these reactions are thought to be associated with HLA-B*1502. This study aims to investigate the incidence, features and risk factors of OXC-cADRs, and to explore their relation to HLA-B alleles in Southern Han Chinese.MethodsA prospective study was performed to investigate the incidence, features and risk factors of OXC-cADRs, in which 252 new users were recruited. To examine the association between OXC-cADRs and HLA-B alleles, 14 maculopapular eruption (MPE) cases, including 9 additional cases beyond this prospective observation, were genotyped by PCR-SSP and sequencing. Thirty-five OXC-tolerant patients served as controls.ResultsFive patients (2.0%) developed an OXC-cADR, and all were mild MPE. History of other AED allergy (p = 0.005, OR = 121.23) and non-AED allergy (p = 0.006, OR = 59.92) were significant risk factors for OXC-cADRs in multivariate logistic regression analysis. Only one patient with OXC-MPE was positive for HLA-B*1502; and the frequency of HLA-B*1502 in OXC-MPE did not differ significantly from that in OXC-tolerant controls. Four HLA-B*1302 alleles were detected in OXC-MPE cases, which was significantly different from that in general population of southern Han Chinese (p = 0.001, OR = 7.83).ConclusionsThe incidence of OXC-induced cADRs was low, and no severe reactions occurred. Patients with a history of allergy are more susceptible to OXC-cADRs. No significant association between HLA-B*1502 and OXC-MPE was found. The associations between OXC-MPE and HLA alleles warrant further studies." @default.
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• W2052484041 date "2012-10-01" @default.
• W2052484041 modified "2023-10-15" @default.
• W2052484041 title "Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: Incidence, features, risk factors and relation to HLA-B alleles" @default.
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• W2052484041 doi "https://doi.org/10.1016/j.seizure.2012.06.014" @default.
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