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• W2052489476 abstract "PMP1, a regulatory subunit of the yeast plasma membrane H+-ATPase, is a single transmembrane helix protein. Its cytoplasmic C-terminus possesses several positively charged residues and interacts with phosphatidylserine lipids as shown through both 1H- and 2H-NMR experiments. We used all-atom molecular dynamics simulations to obtain atomic-scale data on the effects of membrane interface lipid composition on PMP1 structure and tilt. PMP1 was embedded in two hydrated bilayers, differing in the composition of the interfacial region. The neutral bilayer is composed of POPC (1-palmitoyl-2-oleoyl-3-glycero-phosphatidylcholine) lipids and the negatively charged bilayer is composed of POPC and anionic POPS (1-palmitoyl-2-oleoyl-3-glycero-phosphatidylserine) lipids. Our results were consistent with NMR data obtained previously, such as a lipid sn-2 chain lying on the W28 aromatic ring and in the groove formed on one side of the PMP1 helix. In pure POPC, the transmembrane helix is two residues longer than the initial structure and the helix tilt remains constant at 6 ± 3°. By contrast, in mixed POPC-POPS, the initial helical structure of PMP1 is stable throughout the simulation time even though the C-terminal residues interact strongly with POPS headgroups, leading to a significant increase of the helix tilt within the membrane to 20 ± 5°." @default.
• W2052489476 created "2016-06-24" @default.
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• W2052489476 date "2011-04-01" @default.
• W2052489476 modified "2023-09-29" @default.
• W2052489476 title "Membrane Interface Composition Drives the Structure and the Tilt of the Single Transmembrane Helix Protein PMP1: MD Studies" @default.
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• W2052489476 doi "https://doi.org/10.1016/j.bpj.2011.02.002" @default.
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