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• W2052489620 abstract "During interphase, Rab11-GTPase-containing endosomes recycle endocytic cargo. However, little is known about Rab11 endosomes in mitosis. Here, we show that Rab11 localizes to the mitotic spindle and regulates dynein-dependent endosome localization at poles. We found that mitotic recycling endosomes bind γ-TuRC components and associate with tubulin in vitro. Rab11 depletion or dominant-negative Rab11 expression disrupts astral microtubules, delays mitosis, and redistributes spindle pole proteins. Reciprocally, constitutively active Rab11 increases astral microtubules, restores γ-tubulin spindle pole localization, and generates robust spindles. This suggests a role for Rab11 activity in spindle pole maturation during mitosis. Rab11 depletion causes misorientation of the mitotic spindle and the plane of cell division. These findings suggest a molecular mechanism for the organization of astral microtubules and the mitotic spindle through Rab11-dependent control of spindle pole assembly and function. We propose that Rab11 and its associated endosomes cocontribute to these processes through retrograde transport to poles by dynein." @default.
• W2052489620 created "2016-06-24" @default.
• W2052489620 creator A5013464423 @default.
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• W2052489620 date "2014-03-01" @default.
• W2052489620 modified "2023-10-14" @default.
• W2052489620 title "Rab11 Endosomes Contribute to Mitotic Spindle Organization and Orientation" @default.
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• W2052489620 doi "https://doi.org/10.1016/j.devcel.2014.01.014" @default.
• W2052489620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4030695" @default.
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