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• W2052506044 abstract "Background: Preeclampsia is a common hereditary disease with unclear aetiology and various genetic and environmental components. We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contributes to individual susceptibility to the development of preeclampsia. Methods: The case-control study involved 133 women with preeclampsia and 115 healthy controls. They were genotyped for the K121Q polymorphism in the PC-1 gene. χ2 analysis was used to assess genotype and allele frequency differences between preeclamptic and control women. Results: The frequency of the PC-1 gene 121K allele was found to be equal in the two groups, being 90.2% among women with preeclampsia and 90.4% among controls (p = 0.937; OR = 1.024; 95% CI = 0.564–1.861). Also the genotype distribution of the PC-1 K121Q polymorphism was similar (p = 0.516) in the preeclamptic and control groups. Conclusions: The K121Q polymorphism of the PC-1 gene is unlikely to be a major genetic factor predisposing to preeclampsia in Finnish women." @default.
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• W2052506044 date "2006-01-01" @default.
• W2052506044 modified "2023-09-23" @default.
• W2052506044 title "Plasma Cell Membrane Glycoprotein-1 K121Q Polymorphism in Preeclampsia" @default.
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• W2052506044 doi "https://doi.org/10.1159/000089482" @default.
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