FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052511512> ?p ?o ?g. }

• W2052511512 endingPage "369" @default.
• W2052511512 startingPage "361" @default.
• W2052511512 abstract "Atenolol is a β-adrenergic receptor antagonist (‘β-blocker’) widely used for the treatment of angina, glaucoma, high blood pressure and other related conditions. Since atenolol is not appreciably metabolized in humans, the parent compound is the predominant excretory product, and has been detected in sewage effluent discharges and surface waters. Consequently, atenolol has been chosen as a reference pharmaceutical for a European Union-funded research consortium, known as ERAPharm (http://www.erapharm.org), which focused on the fate and effects of pharmaceuticals in the environment. Here, we present data generated within this project from studies assessing population-relevant effects in a freshwater fish species. Using fathead minnows (Pimephales promelas) as a standard OECD test species, embryo-larval development (early life stage or ELS) and short-term (21 d) adult reproduction studies were undertaken. In the ELS study, the 4 d embryo NOEChatching and LOEChatching values were 10 and >10 mg/L, respectively, and after 28 d, NOECgrowth and LOECgrowth values were 3.2 and 10 mg/L, respectively (arithmetic mean measured atenolol concentrations were >90% of these nominal values). In the short-term reproduction study, NOECreproduction and LOECreproduction values were 10 and >10 mg/L, respectively (mean measured concentrations were 77–96% of nominal values), while the most sensitive endpoint was an increase in male fish condition index, giving NOECcondition index and LOECcondition index values of 1.0 and 3.2 mg/L, respectively. The corresponding measured plasma concentration of atenolol in these fish was 0.0518 mg/L. These data collectively suggest that atenolol has low chronic toxicity to fish under the conditions described, particularly considering the low environmental concentrations reported. These data also allowed the assessment of two theoretical approaches proposed as predictors of the environmental impact of human pharmaceuticals: the Huggett ‘mammalian-fish leverage model’; and the acute:chronic ratio (ACR). The Huggett model gave a measured human: fish effect ratio (ER) of 19.3 for atenolol, which compared well with the predicted ER of 40.98. Moreover, for an ER of 19.3, the model suggests that chronic testing may be warranted, and from our resultant effects data, atenolol does not cause significant chronic effects in fathead minnow at environmentally realistic concentrations. The calculated ACR for atenolol is >31.25, which is far lower than that of 17α-ethinylestradiol and other potent steroidal oestrogens, thus further supporting the observed low toxicity. The data produced for atenolol here fit well with both approaches, but also highlight the importance of generating ‘real’ experimental data with which to calibrate and validate such models." @default.
• W2052511512 created "2016-06-24" @default.
• W2052511512 creator A5001663132 @default.
• W2052511512 creator A5015001678 @default.
• W2052511512 creator A5029170230 @default.
• W2052511512 creator A5029543347 @default.
• W2052511512 creator A5041782907 @default.
• W2052511512 creator A5043556770 @default.
• W2052511512 creator A5053142169 @default.
• W2052511512 creator A5071966420 @default.
• W2052511512 creator A5073216324 @default.
• W2052511512 creator A5084388944 @default.
• W2052511512 date "2008-02-01" @default.
• W2052511512 modified "2023-09-27" @default.
• W2052511512 title "Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)" @default.
• W2052511512 cites W1608086260 @default.
• W2052511512 cites W190781029 @default.
• W2052511512 cites W2004085919 @default.
• W2052511512 cites W2005376792 @default.
• W2052511512 cites W2005695503 @default.
• W2052511512 cites W2034286175 @default.
• W2052511512 cites W2035007027 @default.
• W2052511512 cites W2035733598 @default.
• W2052511512 cites W2037621034 @default.
• W2052511512 cites W2041283704 @default.
• W2052511512 cites W2067961627 @default.
• W2052511512 cites W2068933227 @default.
• W2052511512 cites W2093738509 @default.
• W2052511512 cites W2124565523 @default.
• W2052511512 cites W2145937475 @default.
• W2052511512 cites W2158851782 @default.
• W2052511512 cites W4255004503 @default.
• W2052511512 doi "https://doi.org/10.1016/j.aquatox.2007.11.017" @default.
• W2052511512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18179830" @default.
• W2052511512 hasPublicationYear "2008" @default.
• W2052511512 type Work @default.
• W2052511512 sameAs 2052511512 @default.
• W2052511512 citedByCount "77" @default.
• W2052511512 countsByYear W20525115122012 @default.
• W2052511512 countsByYear W20525115122013 @default.
• W2052511512 countsByYear W20525115122014 @default.
• W2052511512 countsByYear W20525115122015 @default.
• W2052511512 countsByYear W20525115122016 @default.
• W2052511512 countsByYear W20525115122017 @default.
• W2052511512 countsByYear W20525115122018 @default.
• W2052511512 countsByYear W20525115122019 @default.
• W2052511512 countsByYear W20525115122020 @default.
• W2052511512 countsByYear W20525115122021 @default.
• W2052511512 countsByYear W20525115122023 @default.
• W2052511512 crossrefType "journal-article" @default.
• W2052511512 hasAuthorship W2052511512A5001663132 @default.
• W2052511512 hasAuthorship W2052511512A5015001678 @default.
• W2052511512 hasAuthorship W2052511512A5029170230 @default.
• W2052511512 hasAuthorship W2052511512A5029543347 @default.
• W2052511512 hasAuthorship W2052511512A5041782907 @default.
• W2052511512 hasAuthorship W2052511512A5043556770 @default.
• W2052511512 hasAuthorship W2052511512A5053142169 @default.
• W2052511512 hasAuthorship W2052511512A5071966420 @default.
• W2052511512 hasAuthorship W2052511512A5073216324 @default.
• W2052511512 hasAuthorship W2052511512A5084388944 @default.
• W2052511512 hasConcept C115346097 @default.
• W2052511512 hasConcept C134018914 @default.
• W2052511512 hasConcept C140793950 @default.
• W2052511512 hasConcept C18903297 @default.
• W2052511512 hasConcept C2776451064 @default.
• W2052511512 hasConcept C2776525901 @default.
• W2052511512 hasConcept C2908647359 @default.
• W2052511512 hasConcept C2909208804 @default.
• W2052511512 hasConcept C2993305272 @default.
• W2052511512 hasConcept C33070731 @default.
• W2052511512 hasConcept C505870484 @default.
• W2052511512 hasConcept C59659247 @default.
• W2052511512 hasConcept C71924100 @default.
• W2052511512 hasConcept C84393581 @default.
• W2052511512 hasConcept C86803240 @default.
• W2052511512 hasConcept C99454951 @default.
• W2052511512 hasConceptScore W2052511512C115346097 @default.
• W2052511512 hasConceptScore W2052511512C134018914 @default.
• W2052511512 hasConceptScore W2052511512C140793950 @default.
• W2052511512 hasConceptScore W2052511512C18903297 @default.
• W2052511512 hasConceptScore W2052511512C2776451064 @default.
• W2052511512 hasConceptScore W2052511512C2776525901 @default.
• W2052511512 hasConceptScore W2052511512C2908647359 @default.
• W2052511512 hasConceptScore W2052511512C2909208804 @default.
• W2052511512 hasConceptScore W2052511512C2993305272 @default.
• W2052511512 hasConceptScore W2052511512C33070731 @default.
• W2052511512 hasConceptScore W2052511512C505870484 @default.
• W2052511512 hasConceptScore W2052511512C59659247 @default.
• W2052511512 hasConceptScore W2052511512C71924100 @default.
• W2052511512 hasConceptScore W2052511512C84393581 @default.
• W2052511512 hasConceptScore W2052511512C86803240 @default.
• W2052511512 hasConceptScore W2052511512C99454951 @default.
• W2052511512 hasIssue "3" @default.
• W2052511512 hasLocation W20525115121 @default.
• W2052511512 hasLocation W20525115122 @default.
• W2052511512 hasOpenAccess W2052511512 @default.
• W2052511512 hasPrimaryLocation W20525115121 @default.
• W2052511512 hasRelatedWork W1979255489 @default.

• next