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• W2052513825 abstract "The chirality of drugs, with particular reference to agents used in veterinary medicine, is reviewed. Basic concepts of chirality and aspects of the methodology for the separation of enantiomers are considered. Chiral compounds are in common use in animals and their pharmacological actions and side-effects (pharmacodynamics) and absorption into and fate within the body (pharmacokinetics) are of fundamental importance; pharmacodynamic and pharmacokinetic properties of enantiomeric pairs commonly differ and this has major implications for their effective and safe therapeutic use. As examples of the particular significance of chirality in veterinary medicine, the following drug classes are reviewed; benzimidazole anthelmintics, cloprostenol, verapamil, ketamine, halogenated hydrocarbon anaesthetics and 2-arylpropionic acid anti-inflammatory drugs. The implications of chirality for drug product development and approval by registration authorities are discussed." @default.
• W2052513825 created "2016-06-24" @default.
• W2052513825 creator A5007405150 @default.
• W2052513825 creator A5032103742 @default.
• W2052513825 creator A5060663725 @default.
• W2052513825 creator A5083388448 @default.
• W2052513825 date "1997-02-01" @default.
• W2052513825 modified "2023-10-18" @default.
• W2052513825 title "Enantioselective behaviour of drugs used in domestic animals: a review" @default.
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• W2052513825 doi "https://doi.org/10.1046/j.1365-2885.1997.00045.x" @default.
• W2052513825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9049943" @default.
• W2052513825 hasPublicationYear "1997" @default.
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