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• W2052518420 abstract "A series of 1,5-diarylpyrazoles with a substituted benzenesulfonamide moiety was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Some compounds, for example, (±)-2-[4-(5-p-tolyl-3-trifluoromethyl-pyrazole-1-yl)-benzenesulfonylaminooxy]-propionic acid 16 and its disodium salt 21, had a higher in vivo anti-inflammatory activity compared to celecoxib, despite having no in vitro COX-1 or COX-2 inhibitory activity. Their gastrointestinal side effect profile is essentially more favorable than that of celecoxib." @default.
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• W2052518420 date "2007-12-12" @default.
• W2052518420 modified "2023-10-17" @default.
• W2052518420 title "New Celecoxib Derivatives as Anti-Inflammatory Agents" @default.
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• W2052518420 doi "https://doi.org/10.1021/jm070821f" @default.
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