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• W2052522055 abstract "Nitroxides are unreactive towards glutathione in vitro. Interaction of nitroxides with peroxynitrite does not lead to a significant loss of their electron paramagnetic resonance (EPR) signal. However, addition of peroxynitrite to a solution containing glutathione and nitroxides induces an irreversible disappearance of EPR signal of nitroxides and augmentation of glutathione oxidation which is a pro-oxidant effect of these compounds. Nitroxide loss leading to the formation of amine derivatives is initiated by products of glutathione oxidation by peroxynitrite. The pro-oxidant action of nitroxides at micromolar concentrations may be important in view of the proposed use of these compounds as antioxidants." @default.
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• W2052522055 date "2003-08-01" @default.
• W2052522055 modified "2023-10-13" @default.
• W2052522055 title "Pro-oxidative activity of nitroxides in their reactions with glutathione" @default.
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• W2052522055 doi "https://doi.org/10.1016/s0891-5849(03)00306-x" @default.
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