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• W2052531326 abstract "Background. Allogeneic bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI) provide valuable treatments for a range of diseases. However, the therapeutic utility of BMT and DLI is reduced by the high incidence of graft-versus-host disease (GvHD) mediated by activated donor T lymphocytes directed against recipient alloantigens. Methods. Using mouse models, we developed and evaluated a strategy to selectively enhance activation-induced cell death (AICD) of anti-recipient T cells within transplant donor cell populations, with the goal of reducing GvHD. Responder T lymphocytes were incubated ex vivo with irradiated allogenic stimulator cells in a mixed lymphocyte reaction (MLR) in the presence of soluble Fas ligand (sFasL) to induce AICD in alloreactive cells. Results. This ex vivo sFasL treatment reduced proliferation to the allogeneic stimulator cells in vitro and abrogated acute GvHD capacity in vivo. In contrast, the secondary immune responsiveness of the ex vivo sFasL-treated responder T cells to an unrelated model antigen was preserved. Furthermore, upon adoptive transfer in a DLI model, ex vivo sFasL-treated T cells were able to reject a model tumor. Finally, ex vivo sFasL treatment of bone marrow cells did not reduce their hematopoietic engraftment capacity. Conclusions. Thus, ex vivo treatment with sFasL appears to have potential for translation to clinical cell processing of BMT allografts and DLI infusions." @default.
• W2052531326 created "2016-06-24" @default.
• W2052531326 creator A5047214928 @default.
• W2052531326 creator A5071883681 @default.
• W2052531326 creator A5072346965 @default.
• W2052531326 date "2006-08-27" @default.
• W2052531326 modified "2023-09-23" @default.
• W2052531326 title "Ex Vivo Soluble Fas Ligand Treatment of Donor Cells to Selectively Reduce Murine Acute Graft Versus Host Disease" @default.
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• W2052531326 doi "https://doi.org/10.1097/01.tp.0000229435.58898.c5" @default.
• W2052531326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16926590" @default.
• W2052531326 hasPublicationYear "2006" @default.
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