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- W2052531799 abstract "Se ha descrito una elevada prevalencia de anticuerpos anticélula parietal gástrica (ACPG) en niños con enfermedad tiroidea autoinmunitaria (ETAI). El objetivo de este trabajo fue determinar la prevalencia de marcadores de gastritis autoinmunitaria en niños con ETAI. Se incluyó a 26 pacientes con ETAI. Se realizaron hemograma, valores plasmáticos de vitamina B12, ácido fólico, gastrina y ACPG. Se estudió también la comorbilidad de otras enfermedades autoinmunitarias. Los valores de tiroxina libre y tirotropina fueron normales con tratamiento hormonal sustitutivo. Los valores de hemoglobina, volumen corpuscular medio, hemoglobina corpuscular media, vitamina B12, ácido fólico y gastrina estaban en rango de normalidad en todos los niños. Se detectaron 6 casos de diabetes mellitus de tipo 1 (DM1) y 2 de ellos también tenían enfermedad celíaca (EC). Se halló ACPG en una niña hipertiroidea de 14 años sin comorbilidad autoinmune. La ETAI se asocia a otras enfermedades de similar etiología, principalmente DM1 y EC. La presencia de ACPG es un marcador precoz y sensible de gastritis autoinmunitaria. A high prevalence of parietal cell antibodies (PCA) has been reported in children with autoimmune thyroid disease (AITD). The aim of this study was to determine the prevalence of autoimmune gastritis markers among children diagnosed as AITD. We studied 26 patients with AITD. Basal samples were taken to determine: hemogram, vitamin B12 and folic acid plasmatic levels, gastrin plasmatic levels, and PCA's determination. Other autoimmune disease comorbility were also studied. Free T4 and TSH values were normal, with hormonal substitutive treatment. Hb, MCV, HCM, vitamine B12, folic acid and gastrin were in normal range for all 26 patients. We reported 6 cases diabetes mellitus type 1 and 2 of celiac disease. A single patient was PCA positive. It was a 14-year-old hyperthyroid girl without any other autoimmune disease. AITD in childhood and adolescence is associated with other autoimmune diseases, specially DM1 and CD. PCA becomes an early and sensitive marker to detect autoinmune gastritis." @default.
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- W2052531799 date "2009-09-01" @default.
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- W2052531799 title "Enfermedad tiroidea autoinmunitaria: posibilidad de asociación a gastritis autoinmunitaria" @default.
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- W2052531799 doi "https://doi.org/10.1016/j.anpedi.2009.05.018" @default.
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