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- W2052532005 abstract "A dense population of rats, Rattus norvegicus (Berk.), infesting a refuse tip, was fed plain cereal bait for 3 weeks and then the same bait treated at 0.05% with a synthetic oestrogen, the 3-cyclopentyl ether of 17 δ-hexa-1′, 3′-diynyloestra-1,3,5(10)-trien-17 β-ol (BDH 10131) for 6 days. Rats were sampled by trapping immediately before the treatment and at 4–10 weekly intervals afterwards over the next 56 weeks. Similar samplings were done at a second tip, used as a control, over a period of 32 weeks. The trapping data indicated that the reproductive potential of the treated rats was severely impaired. Sub-adult animals of either sex were not caught later than 12-weeks post-treatment, the average body-weight of the adults trapped tended to increase at successive samplings and trapping success fell. In contrast, sub-adults were found in each sample taken at the control tip and trapping success remained fairly constant throughout. Marked differences between the treated and the control rats were found at autopsy. A majority of the adult males sampled in the 16-week period after the treatment had atrophied testes laying in the abdominal position. The fertility of the treated adult females was also seriously affected. No successfully breeding females were caught until 26-weeks post-treatment. At the control tip most of the adult males caught had scrotal testes and pregnant females were present in each sample. The results of the BDH 10131 treatment are discussed in relation to similar field studies done using two other synthetic oestrogens mestranol and quinoestrol, and to practical aspects." @default.
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- W2052532005 date "1974-01-01" @default.
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- W2052532005 title "The effects of an oestrogenic steroid on the reproduction of wild rats, Rattus norvegicus (Berk.)" @default.
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- W2052532005 doi "https://doi.org/10.1016/0304-3746(74)90007-9" @default.
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