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• W2052534174 abstract "first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessShort Note 2,2,2-Trichloro-1,1-dimethylethyl 4-methylbenzoate by Lajos Kovács 1,*, Péter Forgó 2 and Zoltán Kele 1 1 Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary 2 Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary * Author to whom correspondence should be addressed. Molbank 2004, 2004(1), M379; https://doi.org/10.3390/M379 Received: 16 October 2003 / Accepted: 11 March 2004 / Published: 29 March 2004 Download Download PDF Download PDF with Cover Download XML Download Epub Download Supplementary Material Versions Notes In our previous work we have demonstrated the utility of the 2,2,2-trichloro-1,1-dimethylethyl (β,β,β-trichloro-tert-butyl, Tcb) group for the protection of carboxylic acids [1]. Herein we would like to describe the preparation of one of their representatives, the title aromatic ester. This compound was mentioned by Gupta and Srivastava [2] but it was not described in detail. Experimental: Freshly prepared anhydrous zinc chloride (1.90 g, 13.9 mmol) was chilled in an ice-bath, then 4-methylbenzoyl chloride (10.75 g, 69.5 mmol) and anhydrous β,β,β-trichloro-tert-butanol (8.225 g, 46.3 mmol, prepared by in vacuo drying of the commercial hemihydrate over phosphorus pentoxide) were added, each in one portion. The flask was removed from the ice-bath and gently shaken to initiate the evolution of hydrogen chloride. When the gas evolution had subsided the reaction mixture was heated at 100 °C for 2 h. The mixture was diluted with diethyl ether (200 mL), extracted with cold satd. NaHCO3 solution (3x100 mL) and brine (100 mL), respectively. The organic phase was dried (MgSO4) and evaporated. The oily residue solidified upon standing (13.167 g, 96%, TLC: slightly contaminated) and it was recrystallized from ethanol (15 mL) to afford the product (9.088 g, 66%). Mp. 84.6-86.3 °C (lit. [2] 85 °C). TLC: light petroleum-ethyl acetate 95:5, Rf: 0.55. Anal. calcd. for C12H13Cl3O2 (295.589): C, 48.76; H, 4.43; Cl, 35.98%; found C, 48.90; H, 4.37; Cl, 35.72%. 1H NMR (CDCl3, 500 MHz, ppm): 2.04 (s, 6H, (CH3)2C), 2.42 (s, 3H, arom. CH3), 7.25 (d, 2H, J=8.3 Hz, arom. CHs), 7.95 (d, 2H, J=8.3 Hz, arom. CHs). 13C NMR (CDCl3, 125 MHz, ppm, assignment based on HMBC and HMQC experiments, asterisks denote interchangeable assignments): 21.41 ((CH3)2C*), 21.66 (arom. CH3*), 88.98 (CCl3), 106.54 ((CH3)2C), 127.94 (C-4), 129.16 (arom. CHs), 129.85 (arom. CHs), 143.94 (C-1), 164.52 (COO). CI-MS (isobutane, m/z): 297, 295 ([M+H]+, isotopic peaks), 263, 261 ([M-Cl]+, isotopic peaks). The calculated peak distributions correspond to the expected structure. Supplementary materialsSupplementary File 1Supplementary File 2Supplementary File 3References:L. Kovács, P.; Forgó, Z. Kele: Fourth International Electronic Conference on Synthetic Organic Chemistry. abstr. no. a0076. ( http://www.unibas.ch/mdpi/ecsoc-4/a0076/a0076.htm).I. Gupta, N. P. Srivastava: Recl. Trav. Chim. Pays-Bas. 1956, 75, 48–50. [Google Scholar]Sample availability: sample available from the authors. © 2004 MDPI. All rights reserved. Share and Cite MDPI and ACS Style Kovács, L.; Forgó, P.; Kele, Z. 2,2,2-Trichloro-1,1-dimethylethyl 4-methylbenzoate. Molbank 2004, 2004, M379. https://doi.org/10.3390/M379 AMA Style Kovács L, Forgó P, Kele Z. 2,2,2-Trichloro-1,1-dimethylethyl 4-methylbenzoate. Molbank. 2004; 2004(1):M379. https://doi.org/10.3390/M379 Chicago/Turabian Style Kovács, Lajos, Péter Forgó, and Zoltán Kele. 2004. 2,2,2-Trichloro-1,1-dimethylethyl 4-methylbenzoate Molbank 2004, no. 1: M379. https://doi.org/10.3390/M379 Find Other Styles Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here. Article Metrics No No Article Access Statistics For more information on the journal statistics, click here. Multiple requests from the same IP address are counted as one view." @default.
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• W2052534174 title "2,2,2-Trichloro-1,1-dimethylethyl 4-methylbenzoate" @default.
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