Matches in SemOpenAlex for { <https://semopenalex.org/work/W205253437> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W205253437 endingPage "109" @default.
- W205253437 startingPage "97" @default.
- W205253437 abstract "Leprosy, a chronic infectious disease caused by Mycobacterium leprae, has provided extraordinary possibilities for gaining insight into immunoregulatory mechanisms in man (Bloom 1986). The disease is not a single entity but rather presents a spectrum of clinical and histopathological manifestations that correlate extraordinarily well with cell-mediated immunity (Ridley and Jopling 1966). Patients at the tuberculoid end of the spectrum characteristically have few localized lesions, containing rare organisms, and mount a strong cell-mediated immune response that ultimately kills and clears the bacilli. At the other end of the spectrum, patients with the lepromatous form have numerous disseminated skin lesions containing enormously high numbers of acid-fast bacilli and show specific immunological unresponsiveness to antigens of M. leprae, in vivo and in vitro (Bloom and Mehra 1984). Antibodies to M. leprae are found throughout the spectrum, the highest levels occurring in the lepromatous disease, indicating that they are unlikely to play a major role in protection. On the other hand, there is a striking inverse correlation between level of cell-mediated immunity to antigens of M. leprae and the growth of the organism in the tissues. The selective and specific cell-mediated unresponsiveness at the lepromatous end of the spectrum to antigens of M. leprae, provides a unique opportunity for exploring mechanisms of tolerance in man (Bloom and Mehra 1984)." @default.
- W205253437 created "2016-06-24" @default.
- W205253437 creator A5052850535 @default.
- W205253437 creator A5070324359 @default.
- W205253437 date "1990-01-01" @default.
- W205253437 modified "2023-09-26" @default.
- W205253437 title "T-Lymphocytes in Leprosy Lesions" @default.
- W205253437 cites W145291166 @default.
- W205253437 cites W1523767929 @default.
- W205253437 cites W1546378938 @default.
- W205253437 cites W1570019182 @default.
- W205253437 cites W1572828602 @default.
- W205253437 cites W1594156949 @default.
- W205253437 cites W1970156510 @default.
- W205253437 cites W1971610750 @default.
- W205253437 cites W1981621217 @default.
- W205253437 cites W1984307342 @default.
- W205253437 cites W1988791393 @default.
- W205253437 cites W2003299672 @default.
- W205253437 cites W2012204136 @default.
- W205253437 cites W2038709060 @default.
- W205253437 cites W2046583093 @default.
- W205253437 cites W2046690548 @default.
- W205253437 cites W2052048121 @default.
- W205253437 cites W2053163514 @default.
- W205253437 cites W2069947334 @default.
- W205253437 cites W2070192407 @default.
- W205253437 cites W2079588771 @default.
- W205253437 cites W2088354306 @default.
- W205253437 cites W2103121825 @default.
- W205253437 cites W2121579952 @default.
- W205253437 cites W2128726372 @default.
- W205253437 cites W2136506770 @default.
- W205253437 cites W2137655050 @default.
- W205253437 cites W2186796959 @default.
- W205253437 cites W2317961872 @default.
- W205253437 cites W2340679956 @default.
- W205253437 cites W4256453315 @default.
- W205253437 cites W4313314670 @default.
- W205253437 doi "https://doi.org/10.1007/978-3-642-74983-4_7" @default.
- W205253437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2137768" @default.
- W205253437 hasPublicationYear "1990" @default.
- W205253437 type Work @default.
- W205253437 sameAs 205253437 @default.
- W205253437 citedByCount "4" @default.
- W205253437 countsByYear W2052534372021 @default.
- W205253437 crossrefType "book-chapter" @default.
- W205253437 hasAuthorship W205253437A5052850535 @default.
- W205253437 hasAuthorship W205253437A5070324359 @default.
- W205253437 hasConcept C147483822 @default.
- W205253437 hasConcept C159654299 @default.
- W205253437 hasConcept C203014093 @default.
- W205253437 hasConcept C2779341262 @default.
- W205253437 hasConcept C2779823659 @default.
- W205253437 hasConcept C2779846462 @default.
- W205253437 hasConcept C2780695269 @default.
- W205253437 hasConcept C3017875465 @default.
- W205253437 hasConcept C86803240 @default.
- W205253437 hasConcept C8891405 @default.
- W205253437 hasConcept C89423630 @default.
- W205253437 hasConceptScore W205253437C147483822 @default.
- W205253437 hasConceptScore W205253437C159654299 @default.
- W205253437 hasConceptScore W205253437C203014093 @default.
- W205253437 hasConceptScore W205253437C2779341262 @default.
- W205253437 hasConceptScore W205253437C2779823659 @default.
- W205253437 hasConceptScore W205253437C2779846462 @default.
- W205253437 hasConceptScore W205253437C2780695269 @default.
- W205253437 hasConceptScore W205253437C3017875465 @default.
- W205253437 hasConceptScore W205253437C86803240 @default.
- W205253437 hasConceptScore W205253437C8891405 @default.
- W205253437 hasConceptScore W205253437C89423630 @default.
- W205253437 hasLocation W2052534371 @default.
- W205253437 hasLocation W2052534372 @default.
- W205253437 hasOpenAccess W205253437 @default.
- W205253437 hasPrimaryLocation W2052534371 @default.
- W205253437 hasRelatedWork W163412548 @default.
- W205253437 hasRelatedWork W1926373868 @default.
- W205253437 hasRelatedWork W2078683391 @default.
- W205253437 hasRelatedWork W2244947588 @default.
- W205253437 hasRelatedWork W2279742172 @default.
- W205253437 hasRelatedWork W2469970871 @default.
- W205253437 hasRelatedWork W2470017242 @default.
- W205253437 hasRelatedWork W2515266305 @default.
- W205253437 hasRelatedWork W2591098767 @default.
- W205253437 hasRelatedWork W797848406 @default.
- W205253437 isParatext "false" @default.
- W205253437 isRetracted "false" @default.
- W205253437 magId "205253437" @default.
- W205253437 workType "book-chapter" @default.