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- W2052536265 abstract "First developed by the International Society for Heart and Lung Transplantation (ISHLT) in 1990, the standardized grading method to determine acute cellular rejection (ACR) on endo-myocardial biopsy has since been reviewed and updated (2004). In 2013, the ISHLT issued a further consensus working formulation for the standardization of nomenclature towards pathological diagnosis of antibody-mediated rejection (AMR) in heart transplantation.This survey describes and compares current reporting protocols at three European cardiac transplant centres (Manchester; Berlin and Vienna). The objectives are to identify similarities and variations between the three centres and to compare working practices at these centres with respect to the consensus guidelines issued by the ISHLT. The overall aim is to highlight areas of good practice and identify any possible areas requiring modifications. Detailed protocols with respect to processing (including tissue sectioning and staining) and reporting of antibody mediated resection were collated from the three centres (see table 1). All three centres incorporate the recommended ISHLT 2004 reporting guidelines for assessment of acute cellular rejection with additional comment on the 1990 grade by at least one centre. Although a wide variation is noted in the range of antibodies being used, however, C4d is used at all three centres as recommended by the 2013 ISHLT guidance on AMR reporting. Special stains for collagen are not performed at one centre. Overall, this survey highlights a largely similar approach to reporting practice across the three centres with evidence of a greater acceptance of the 2004 reporting guidelines. The general acceptance and implementation of standardized criteria and methodologies for diagnosing ACR and AMR allows for a more robust interpretation and improved correlation with diagnosis of rejection and patient management." @default.
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- W2052536265 date "2015-04-01" @default.
- W2052536265 modified "2023-09-27" @default.
- W2052536265 title "Cardiac Post-Transplant Biopsy Tissue Processing and Reporting Protocols for Rejection: A Comparative Survey of Routine Practice Across Three European Centres" @default.
- W2052536265 doi "https://doi.org/10.1016/j.healun.2015.01.901" @default.
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