Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052536273> ?p ?o ?g. }
- W2052536273 endingPage "199" @default.
- W2052536273 startingPage "187" @default.
- W2052536273 abstract "Most clinical practice guidelines recommend restrictive red blood cell (RBC) transfusion practices with the goal of minimizing transmission of blood-borne pathogens. The purpose of this review is to compare clinical outcomes in patients randomized to restrictive versus liberal transfusion thresholds (triggers). We conducted a search of OVID Medline, Current Contents, the Cochrane Library, and bibliographies of published studies. Our search strategies used a combination of key-word terms as text and MeSH headings relating to transfusion triggers. We included trials if the comparison groups were assigned on the basis of a clear transfusion trigger or threshold, and the study was randomized with a concurrent control group. Eligibility of studies was assessed by 2 independent raters, with disagreements resolved by consensus. Disagreements not resolved by consensus were referred to a third party for review. Two raters assessed the methodologic quality of the trials modified from the methods of Schultz. The main study outcomes probability of receiving an RBC transfusion, volume of RBCs transfused, hematocrit levels, mortality, and length of hospital stay. Ten trials, which reported outcomes for a total of 1,780 patients, were included. Five studies were in surgical patients, 3 were in the setting of acute blood loss and trauma, and 2 involved intensive care unit patients. Transfusion triggers varied between 7 and 10 g/dL (most often they were 8 or 9 g/dL). Being randomized to a restrictive transfusion trigger group had the following average effects: the probability of receiving an RBC transfusion was reduced by 42% (relative risk, 0.58; 95% confidence interval [CI] 0.47, 0.71), the volume of RBCs was reduced by 0.93 units (95% CI 0.36, 1.5 units), and hematocrit values were 5.6 % lower (95% CI 3.5, 7.7%). Mortality, rates of cardiac events, morbidity, and length of hospital stay were unaffected. The limited published evidence supports the use of restrictive transfusion triggers in patients who are free of serious cardiac disease. However, most of the data on clinical outcomes were generated by a single trial. The effects of conservative transfusion triggers on functional status, morbidity, and mortality, particularly in patients with cardiac disease, need to be tested in further large clinical trials. In countries with inadequate screening of donor blood, the data may constitute a stronger basis for avoiding transfusion with allogeneic RBCs." @default.
- W2052536273 created "2016-06-24" @default.
- W2052536273 creator A5000960746 @default.
- W2052536273 creator A5016832904 @default.
- W2052536273 creator A5017708297 @default.
- W2052536273 creator A5039446646 @default.
- W2052536273 creator A5045252660 @default.
- W2052536273 date "2002-07-01" @default.
- W2052536273 modified "2023-10-18" @default.
- W2052536273 title "Transfusion triggers: A systematic review of the literature*" @default.
- W2052536273 cites W115624719 @default.
- W2052536273 cites W127034668 @default.
- W2052536273 cites W170502642 @default.
- W2052536273 cites W1960469696 @default.
- W2052536273 cites W1967229886 @default.
- W2052536273 cites W1969201191 @default.
- W2052536273 cites W1972373866 @default.
- W2052536273 cites W1987984301 @default.
- W2052536273 cites W1989816453 @default.
- W2052536273 cites W1993287460 @default.
- W2052536273 cites W2000547913 @default.
- W2052536273 cites W2005089240 @default.
- W2052536273 cites W2011112804 @default.
- W2052536273 cites W2011932878 @default.
- W2052536273 cites W2013824941 @default.
- W2052536273 cites W2015436972 @default.
- W2052536273 cites W2027008837 @default.
- W2052536273 cites W2039153021 @default.
- W2052536273 cites W2039586561 @default.
- W2052536273 cites W2042062134 @default.
- W2052536273 cites W2056798400 @default.
- W2052536273 cites W2072224369 @default.
- W2052536273 cites W2075064256 @default.
- W2052536273 cites W2075236046 @default.
- W2052536273 cites W2077710671 @default.
- W2052536273 cites W2078025540 @default.
- W2052536273 cites W2081670726 @default.
- W2052536273 cites W2082576891 @default.
- W2052536273 cites W2089833458 @default.
- W2052536273 cites W2100009404 @default.
- W2052536273 cites W2107328434 @default.
- W2052536273 cites W2109291212 @default.
- W2052536273 cites W2116257187 @default.
- W2052536273 cites W2125864132 @default.
- W2052536273 cites W2127110326 @default.
- W2052536273 cites W21341163 @default.
- W2052536273 cites W2134122718 @default.
- W2052536273 cites W2152623025 @default.
- W2052536273 cites W2156969032 @default.
- W2052536273 cites W2164409408 @default.
- W2052536273 cites W2168865003 @default.
- W2052536273 cites W2319983832 @default.
- W2052536273 cites W2323849691 @default.
- W2052536273 cites W2341309557 @default.
- W2052536273 cites W2341616068 @default.
- W2052536273 cites W2417444273 @default.
- W2052536273 cites W256873987 @default.
- W2052536273 cites W2616141209 @default.
- W2052536273 cites W2730003010 @default.
- W2052536273 cites W2916043841 @default.
- W2052536273 cites W3026093479 @default.
- W2052536273 cites W2068398751 @default.
- W2052536273 cites W2404152353 @default.
- W2052536273 doi "https://doi.org/10.1053/tmrv.2002.33461" @default.
- W2052536273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12075558" @default.
- W2052536273 hasPublicationYear "2002" @default.
- W2052536273 type Work @default.
- W2052536273 sameAs 2052536273 @default.
- W2052536273 citedByCount "219" @default.
- W2052536273 countsByYear W20525362732012 @default.
- W2052536273 countsByYear W20525362732013 @default.
- W2052536273 countsByYear W20525362732014 @default.
- W2052536273 countsByYear W20525362732015 @default.
- W2052536273 countsByYear W20525362732016 @default.
- W2052536273 countsByYear W20525362732017 @default.
- W2052536273 countsByYear W20525362732018 @default.
- W2052536273 countsByYear W20525362732019 @default.
- W2052536273 countsByYear W20525362732020 @default.
- W2052536273 countsByYear W20525362732021 @default.
- W2052536273 countsByYear W20525362732022 @default.
- W2052536273 countsByYear W20525362732023 @default.
- W2052536273 crossrefType "journal-article" @default.
- W2052536273 hasAuthorship W2052536273A5000960746 @default.
- W2052536273 hasAuthorship W2052536273A5016832904 @default.
- W2052536273 hasAuthorship W2052536273A5017708297 @default.
- W2052536273 hasAuthorship W2052536273A5039446646 @default.
- W2052536273 hasAuthorship W2052536273A5045252660 @default.
- W2052536273 hasConcept C126322002 @default.
- W2052536273 hasConcept C168563851 @default.
- W2052536273 hasConcept C17744445 @default.
- W2052536273 hasConcept C177713679 @default.
- W2052536273 hasConcept C189708586 @default.
- W2052536273 hasConcept C194828623 @default.
- W2052536273 hasConcept C199539241 @default.
- W2052536273 hasConcept C2776376669 @default.
- W2052536273 hasConcept C2776478404 @default.
- W2052536273 hasConcept C2779473830 @default.
- W2052536273 hasConcept C2780014101 @default.