FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052538861> ?p ?o ?g. }

• W2052538861 endingPage "1372" @default.
• W2052538861 startingPage "1362" @default.
• W2052538861 abstract "Abstract Binding of p53 to miR‐34a promoter activates the expression of tumor‐suppressive miR‐34a. Oncogenic human papillomavirus (HPV) infection downregulates miR‐34a expression through viral E6 degradation of p53. In our report, we found that miR‐34a specifically targets p18Ink4c, a CDK4 and CDK6 inhibitor induced by E2F transactivation. HPV18 + HeLa cells with ectopic miR‐34a expression or by E6 siRNA knockdown‐induced expression of endogenous miR‐34a exhibited a substantial reduction of p18Ink4c in a dose‐dependent manner, but had no effect on p16Ink4a, another member of CDK4/6 inhibitor family. In contrast, de novo infection by oncogenic HPVs of human keratinocyte‐derived raft tissues increased p18Ink4c expression. Suppression of endogenous miR‐34a in cell lines with a miR‐34a inhibitor also increased p18Ink4c. We found that miR‐34a suppresses the expression of p18Ink4c by binding to a specific seed match in the 5′ UTR of p18Ink4c. Further investigation found remarkable increase of p18Ink4c in cervical precancer lesions and cervical cancer. Immunohistochemical staining of cervical tissue arrays showed increased expression of p18Ink4c in 68% of cervical cancer, 8.3% of chronic cervical inflammation and 4.8% of normal cervix. Although p18Ink4c inhibits cell proliferation in general and regulates E2F1 expression in HCT116 cells, it appears not to function as a tumor suppressor in cervical cancer cells lacking an intact G1 checkpoint because of viral E7 degradation of pRB. In summary, our study demonstrates an intimate connection among oncogenic HPV E6, p53, miR‐34a and p18Ink4c and identifies p18Ink4c as a possible biomarker for cervical cancer." @default.
• W2052538861 created "2016-06-24" @default.
• W2052538861 creator A5045409917 @default.
• W2052538861 creator A5056072896 @default.
• W2052538861 creator A5086389738 @default.
• W2052538861 creator A5086610984 @default.
• W2052538861 date "2011-02-26" @default.
• W2052538861 modified "2023-10-18" @default.
• W2052538861 title "Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway" @default.
• W2052538861 cites W1968495382 @default.
• W2052538861 cites W1985068587 @default.
• W2052538861 cites W1985097719 @default.
• W2052538861 cites W1987350137 @default.
• W2052538861 cites W1998218812 @default.
• W2052538861 cites W2001627329 @default.
• W2052538861 cites W2006173503 @default.
• W2052538861 cites W2025021599 @default.
• W2052538861 cites W2031475327 @default.
• W2052538861 cites W2033156691 @default.
• W2052538861 cites W2038167014 @default.
• W2052538861 cites W2050121488 @default.
• W2052538861 cites W2054616973 @default.
• W2052538861 cites W2059848983 @default.
• W2052538861 cites W2063881354 @default.
• W2052538861 cites W2073513377 @default.
• W2052538861 cites W2074210527 @default.
• W2052538861 cites W2080084006 @default.
• W2052538861 cites W2080675426 @default.
• W2052538861 cites W2082674152 @default.
• W2052538861 cites W2083158631 @default.
• W2052538861 cites W2083381199 @default.
• W2052538861 cites W2088948404 @default.
• W2052538861 cites W2093055313 @default.
• W2052538861 cites W2093364695 @default.
• W2052538861 cites W2100651747 @default.
• W2052538861 cites W2101196984 @default.
• W2052538861 cites W2102919621 @default.
• W2052538861 cites W2108848219 @default.
• W2052538861 cites W2109118354 @default.
• W2052538861 cites W2109557991 @default.
• W2052538861 cites W2116799486 @default.
• W2052538861 cites W2121619780 @default.
• W2052538861 cites W2123845663 @default.
• W2052538861 cites W2126860097 @default.
• W2052538861 cites W2135573944 @default.
• W2052538861 cites W2135779855 @default.
• W2052538861 cites W2139376220 @default.
• W2052538861 cites W2144154026 @default.
• W2052538861 cites W2149146453 @default.
• W2052538861 cites W2156843318 @default.
• W2052538861 cites W2158687296 @default.
• W2052538861 cites W2161919763 @default.
• W2052538861 cites W2166997624 @default.
• W2052538861 cites W2167719113 @default.
• W2052538861 cites W2170334007 @default.
• W2052538861 cites W4214489112 @default.
• W2052538861 doi "https://doi.org/10.1002/ijc.25800" @default.
• W2052538861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3086996" @default.
• W2052538861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21128241" @default.
• W2052538861 hasPublicationYear "2011" @default.
• W2052538861 type Work @default.
• W2052538861 sameAs 2052538861 @default.
• W2052538861 citedByCount "65" @default.
• W2052538861 countsByYear W20525388612012 @default.
• W2052538861 countsByYear W20525388612013 @default.
• W2052538861 countsByYear W20525388612014 @default.
• W2052538861 countsByYear W20525388612015 @default.
• W2052538861 countsByYear W20525388612016 @default.
• W2052538861 countsByYear W20525388612017 @default.
• W2052538861 countsByYear W20525388612018 @default.
• W2052538861 countsByYear W20525388612019 @default.
• W2052538861 countsByYear W20525388612020 @default.
• W2052538861 countsByYear W20525388612021 @default.
• W2052538861 countsByYear W20525388612022 @default.
• W2052538861 crossrefType "journal-article" @default.
• W2052538861 hasAuthorship W2052538861A5045409917 @default.
• W2052538861 hasAuthorship W2052538861A5056072896 @default.
• W2052538861 hasAuthorship W2052538861A5086389738 @default.
• W2052538861 hasAuthorship W2052538861A5086610984 @default.
• W2052538861 hasBestOaLocation W20525388612 @default.
• W2052538861 hasConcept C104317684 @default.
• W2052538861 hasConcept C119056186 @default.
• W2052538861 hasConcept C121608353 @default.
• W2052538861 hasConcept C127561419 @default.
• W2052538861 hasConcept C1292079 @default.
• W2052538861 hasConcept C150194340 @default.
• W2052538861 hasConcept C173396325 @default.
• W2052538861 hasConcept C185592680 @default.
• W2052538861 hasConcept C190232843 @default.
• W2052538861 hasConcept C199649820 @default.
• W2052538861 hasConcept C199835354 @default.
• W2052538861 hasConcept C29537977 @default.
• W2052538861 hasConcept C502942594 @default.
• W2052538861 hasConcept C54355233 @default.
• W2052538861 hasConcept C55493867 @default.
• W2052538861 hasConcept C81885089 @default.
• W2052538861 hasConcept C83258922 @default.
• W2052538861 hasConcept C86803240 @default.

• next