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• W2052546602 abstract "Abstract The effect of a single oral dose of DDT (150 mg/kg body wt) has been investigated on the intestinal uptake of certain nutrients and on brush border enzymes in protein-calorie-malnourished monkeys. In contrast to the stimulatory action of DDT on intestinal functions in normal-fed monkeys (A. Mahmood, N. Agarwal, S. Sanyal, P.K. Dudeja, and D. Subrahmanyam, Pest. Biochem. Physiol. 12 , 141 (1979)) pesticide feeding to malnourished animals inhibited the uptake of alanine and phenylalanine and depressed sucrase, lactase, and leucine amino-peptidase activities. Glucose and leucine uptake was also reduced, albeit insignificantly and alkaline phosphatase activity was unaffected under these conditions. Protein-energy malnutrition per se considerably elevated the uptake of nutrients and disaccharidase activities. Analysis of the chemical composition of microvillus membrane in underfed and pesticide-exposed malnourished animals revealed alterations in protein, sialic acid, and phospholipid fractions of the brush borders. Membrane cholesterol and triglyceride contents remained unaltered in protein-energy-deficient and DDT-fed monkeys." @default.
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• W2052546602 date "1981-04-01" @default.
• W2052546602 modified "2023-09-22" @default.
• W2052546602 title "Effect of a single oral dose of DDT on intestinal uptake of nutrients and brush border enzymes in protein-calorie-malnourished monkeys" @default.
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• W2052546602 doi "https://doi.org/10.1016/0048-3575(81)90079-1" @default.
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