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- W2052546670 abstract "To compare the effects of continuous noncombined transdermal estradiol versus oral conjugated estrogen on serum sex hormone-binding globulin (SHBG) levels prior to and during the 10th and 22nd weeks of therapy in patients with surgical menopause.Open, comparative trial. Patients were consecutively assigned to three groups: group 1 (n = 18) received continuous transdermal estradiol (0.050 mg/day), group 2 (n = 18) continuous oral conjugated estrogens (0.625 mg/day), whereas group 3 (n = 15) received no treatment. Serum SHBG levels were determined before treatment and after 10 and 22 weeks of treatment.Serum SHBG increased significantly with oral conjugated estrogens at 10 (p < 0.01) and 22 weeks (p < 0.01) compared with baseline. With transdermal estrogens there was a much smaller increase of SHBG. At 22 weeks, this increase was significant compared with baseline (p < 0.05), but not compared with the control group (p > 0.05).Transdermal estrogen has no effect on SHBG, whereas oral conjugated estrogens causes considerable increase." @default.
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- W2052546670 date "1997-06-01" @default.
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- W2052546670 title "Twenty two weeks of transdermal estradiol increases sex hormone-binding globulin in surgical menopausal women" @default.
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- W2052546670 doi "https://doi.org/10.1016/s0301-2115(97)02706-1" @default.
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