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- W2052548529 abstract "The mesolimbic and mesocortical circuits are particularly involved in reward-related behavior in humans. Because these systems may be in some way altered in Parkinson's disease (PD), it is likely that some psychiatric manifestations of PD, such as hedonistic homeostatic dysregulation and pathological gambling, as well as impulsive decision making, may be ascribed to their involvement. The aim of the current article was to review recent literature on this topic in order to analyze whether these disturbances share a common ground and whether actual theoretical frameworks on addiction prove a useful tool for their interpretation.Data were identified on searches of MEDLINE/PubMed databases from relevant articles published up until March 2007.All clinical manifestations (hedonistic homeostatic dysregulation, pathological gambling and impulsive decision making) seem to share a common multifaceted ground in which factors related to antiparkinsonian therapy, premorbid personality and progression of disease interact. Theoretical interpretations and conclusions drawn from experimental studies may help to shed light on the underlying pathological mechanisms.Further studies are needed to analyze why, despite a common ground, only some patients develop those neuropsychiatric complications described here." @default.
- W2052548529 created "2016-06-24" @default.
- W2052548529 creator A5015280820 @default.
- W2052548529 creator A5065935573 @default.
- W2052548529 date "2008-04-01" @default.
- W2052548529 modified "2023-10-12" @default.
- W2052548529 title "Reward pathways in Parkinson's disease: Clinical and theoretical implications" @default.
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- W2052548529 doi "https://doi.org/10.1111/j.1440-1819.2008.01756.x" @default.
- W2052548529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18412844" @default.
- W2052548529 hasPublicationYear "2008" @default.
- W2052548529 type Work @default.