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- W2052553567 abstract "Abstract A high performance liquid chromatographic (HPLC) method suitable for routine determination of lamotrigine in a dissolution medium and tablet formulation has been developed. Chromatographic separation was performed on a Gemini C18 (250 mm×4.6 mm i.d., 5 µm) column using a mobile phase of 0.05 M (NH4)H2PO4‐acetonitrile (68∶32, v/v, pH 2.68), delivered at a flow rate of 1.2 mL/min and detected by ultraviolet at 265 nm. The method was validated for specificity, linearity, accuracy, and precision. Additionally, the conditions of the dissolution test for lamotrigine tablets were presented by using: paddle at 50 rpm stirring speed; medium volume of 900 mL; temperature at 37±0.5°C; and pH 1.2 HCl solution, pH 4.5 acetate buffer and pH 6.8 phosphate buffer as dissolution media. The proposed analytical and dissolution methods were applied successfully for the quality control of commercial lamotrigine tablets and the comparison of in vitro performances of their products." @default.
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- W2052553567 date "2008-02-20" @default.
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- W2052553567 title "Development and Validation of a HPLC Method for a Dissolution Test of Lamotrigine Tablets and its Application to Drug Quality Control Studies" @default.
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- W2052553567 doi "https://doi.org/10.1080/10826070801893615" @default.
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