FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052555761> ?p ?o ?g. }

• W2052555761 endingPage "e31153" @default.
• W2052555761 startingPage "e31153" @default.
• W2052555761 abstract "Progression towards type 1 diabetes (T1D) in susceptible patients is linked to a progressive decline in the capacity of regulatory T cells (Treg) to maintain tolerance. As such, therapies aimed at redressing the failing Treg compartment have been the subject of intense investigation. Treg dysfunction in T1D has recently been linked to a reduced capacity of antigen presenting cells (APCs) to maintain Treg function rather than Treg intrinsic defects. This suggests that therapies aimed simply at addressing the failing Treg compartment are unlikely to provide long-term protection. Here, we demonstrate that modulation of the inflammatory status of CD11b+CD11c- APCs favors the upregulation of protective Tregs in a mouse model of T1D. We further demonstrate that reduced expression of the costimulatory molecule CD40 plays a role in this increased immunoregulatory capacity. Strikingly, Treg upregulation resulted exclusively from an increase in natural Tregs rather than the peripheral conversion of conventional T cells. This suggests that modulation of CD11b+ CD11c- APCs inflammatory properties favors the establishment of natural Treg responses that, unlike adaptive Treg responses, are likely to maintain tolerance to a broad range of antigens. As such, modulation of this APC subset represents a potential therapeutic avenue to reestablish peripheral tolerance and protect from autoimmune diseases such as T1D." @default.
• W2052555761 created "2016-06-24" @default.
• W2052555761 creator A5003925456 @default.
• W2052555761 creator A5049534090 @default.
• W2052555761 creator A5058970538 @default.
• W2052555761 creator A5071826511 @default.
• W2052555761 date "2012-02-15" @default.
• W2052555761 modified "2023-09-23" @default.
• W2052555761 title "Immunomodulation of Antigen Presenting Cells Promotes Natural Regulatory T Cells That Prevent Autoimmune Diabetes in NOD Mice" @default.
• W2052555761 cites W1530509485 @default.
• W2052555761 cites W1619959770 @default.
• W2052555761 cites W1685495245 @default.
• W2052555761 cites W1973887349 @default.
• W2052555761 cites W1976365039 @default.
• W2052555761 cites W1978559018 @default.
• W2052555761 cites W1981498390 @default.
• W2052555761 cites W1981993767 @default.
• W2052555761 cites W1996433325 @default.
• W2052555761 cites W2001740313 @default.
• W2052555761 cites W2002967638 @default.
• W2052555761 cites W2017186381 @default.
• W2052555761 cites W2021414400 @default.
• W2052555761 cites W2021713059 @default.
• W2052555761 cites W2032091790 @default.
• W2052555761 cites W2032594763 @default.
• W2052555761 cites W2034306860 @default.
• W2052555761 cites W2036427866 @default.
• W2052555761 cites W2042844150 @default.
• W2052555761 cites W2045932062 @default.
• W2052555761 cites W2055264495 @default.
• W2052555761 cites W2059632969 @default.
• W2052555761 cites W2082137006 @default.
• W2052555761 cites W2083198686 @default.
• W2052555761 cites W2083826829 @default.
• W2052555761 cites W2094027132 @default.
• W2052555761 cites W2095350152 @default.
• W2052555761 cites W2098479780 @default.
• W2052555761 cites W2100996803 @default.
• W2052555761 cites W2111329034 @default.
• W2052555761 cites W2113084815 @default.
• W2052555761 cites W2117576441 @default.
• W2052555761 cites W2117644665 @default.
• W2052555761 cites W2120010406 @default.
• W2052555761 cites W2122371014 @default.
• W2052555761 cites W2122689765 @default.
• W2052555761 cites W2122809282 @default.
• W2052555761 cites W2125758525 @default.
• W2052555761 cites W2128882575 @default.
• W2052555761 cites W2130486201 @default.
• W2052555761 cites W2136129817 @default.
• W2052555761 cites W2137473611 @default.
• W2052555761 cites W2145430279 @default.
• W2052555761 cites W2147579197 @default.
• W2052555761 cites W2149311132 @default.
• W2052555761 cites W2150210328 @default.
• W2052555761 cites W2152642587 @default.
• W2052555761 cites W2155779547 @default.
• W2052555761 cites W2159273584 @default.
• W2052555761 cites W2162937688 @default.
• W2052555761 cites W2169593537 @default.
• W2052555761 cites W4251223296 @default.
• W2052555761 doi "https://doi.org/10.1371/journal.pone.0031153" @default.
• W2052555761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280284" @default.
• W2052555761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22355341" @default.
• W2052555761 hasPublicationYear "2012" @default.
• W2052555761 type Work @default.
• W2052555761 sameAs 2052555761 @default.
• W2052555761 citedByCount "11" @default.
• W2052555761 countsByYear W20525557612012 @default.
• W2052555761 countsByYear W20525557612015 @default.
• W2052555761 countsByYear W20525557612016 @default.
• W2052555761 countsByYear W20525557612019 @default.
• W2052555761 countsByYear W20525557612020 @default.
• W2052555761 countsByYear W20525557612022 @default.
• W2052555761 crossrefType "journal-article" @default.
• W2052555761 hasAuthorship W2052555761A5003925456 @default.
• W2052555761 hasAuthorship W2052555761A5049534090 @default.
• W2052555761 hasAuthorship W2052555761A5058970538 @default.
• W2052555761 hasAuthorship W2052555761A5071826511 @default.
• W2052555761 hasBestOaLocation W20525557611 @default.
• W2052555761 hasConcept C104317684 @default.
• W2052555761 hasConcept C127561419 @default.
• W2052555761 hasConcept C127716648 @default.
• W2052555761 hasConcept C147483822 @default.
• W2052555761 hasConcept C171779818 @default.
• W2052555761 hasConcept C203014093 @default.
• W2052555761 hasConcept C2777016536 @default.
• W2052555761 hasConcept C2777702733 @default.
• W2052555761 hasConcept C2778013207 @default.
• W2052555761 hasConcept C2779919695 @default.
• W2052555761 hasConcept C2780130043 @default.
• W2052555761 hasConcept C55493867 @default.
• W2052555761 hasConcept C71924100 @default.
• W2052555761 hasConcept C86803240 @default.
• W2052555761 hasConcept C8891405 @default.
• W2052555761 hasConcept C95444343 @default.
• W2052555761 hasConceptScore W2052555761C104317684 @default.
• W2052555761 hasConceptScore W2052555761C127561419 @default.

• next