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- W2052565666 abstract "Numerous studies designed to determine the role of ascorbic acid in adrenal cortex function have employed parameters such as urinary corticosteroids, urinary 17-ketosteroids, liver glycogen, and blood leukocytes as indices of adrenal activity. In many cases these observations were interpreted without regard to possible alterations in corticosteroid metabolism by the tissues of the ascorbic acid deficient animal, or in changes in the target organs in this condition. In recent work we pointed out that ascorbic acid nutrition influences the metabolism of the side-chain, and the Δ4,3-ketone structure of the nucleus, of cortisone and desoxycorticosterone. It was shown that in vitro preparations of liver slices of ascorbic acid-deficient animals metabolize greater amounts of the 17-hydroxyl,- 20,21-ketol grouping than do control liver tissues (Bacchus, 1953a). With employment of a superior technique it was also shown that ascorbic acid excess derpresses the metabolism of the side chain," @default.
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- W2052565666 date "1955-11-01" @default.
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- W2052565666 title "INFLUENCE OF CITRIC ACID CYCLE INTERMEDIATES ON THEIN VITROMETABOLISM OF CORTICOSTEROIDS IN ASCORBIC ACID DEFICIENCY1" @default.
- W2052565666 doi "https://doi.org/10.1210/endo-57-5-531" @default.
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