FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052572242> ?p ?o ?g. }

• W2052572242 endingPage "88" @default.
• W2052572242 startingPage "79" @default.
• W2052572242 abstract "During early embryogenesis, the phenotype reflecting the embryonic genotype emerges only as maternal proteins are replaced by embryonically encoded forms, a process known as the maternal-to-embryonic transition (MET). Little is understood about MET for most proteins. This study investigates how complete deficiency of the murine dihydrolipoamide dehydrogenase gene (Dld), a gene that encodes an enzyme of mitochondrial energy metabolism, affects the phenotype of the early embryo and how the MET of the DLD protein affects the phenotype. Dld-deficient (-/-) embryos were found to develop similarly to wild-type (+/+) or heterozygous (+/-) embryos throughout the preimplantation period. These three genotypic classes also have comparable rates of glucose uptake (4.9-5.0 pmoles/embryo/h) and lactate production (0.97-1.0 pmoles/embryo/h). Dld-deficient embryos at the end of the preimplantation stage have 44% of DLD enzyme present in oocytes, a proportion similar to that found in +/+ or +/- embryos. This study demonstrates that Dld-deficient preimplantation embryos are phenotypically normal, as the MET for the DLD enzyme is only partially complete by the end of the preimplantation period. These findings have implications for phenotype- or enzyme-based approaches to identify mutations in Dld and other genes that encode proteins with similar MET kinetic profiles." @default.
• W2052572242 created "2016-06-24" @default.
• W2052572242 creator A5031626342 @default.
• W2052572242 creator A5047168197 @default.
• W2052572242 creator A5050479075 @default.
• W2052572242 creator A5077397169 @default.
• W2052572242 date "2009-01-01" @default.
• W2052572242 modified "2023-09-27" @default.
• W2052572242 title "Maternal enzyme masks the phenotype of mouse embryos lacking dihydrolipoamide dehydrogenase" @default.
• W2052572242 cites W1205396264 @default.
• W2052572242 cites W1483242733 @default.
• W2052572242 cites W1596348596 @default.
• W2052572242 cites W169244232 @default.
• W2052572242 cites W177346750 @default.
• W2052572242 cites W1810010883 @default.
• W2052572242 cites W1924807915 @default.
• W2052572242 cites W1934389460 @default.
• W2052572242 cites W1965116272 @default.
• W2052572242 cites W1982606879 @default.
• W2052572242 cites W1990710362 @default.
• W2052572242 cites W1998826275 @default.
• W2052572242 cites W20000880 @default.
• W2052572242 cites W2000588572 @default.
• W2052572242 cites W2002316686 @default.
• W2052572242 cites W2011269438 @default.
• W2052572242 cites W2011946635 @default.
• W2052572242 cites W2013268532 @default.
• W2052572242 cites W2014171524 @default.
• W2052572242 cites W2020871447 @default.
• W2052572242 cites W2020944325 @default.
• W2052572242 cites W2022050485 @default.
• W2052572242 cites W2023614606 @default.
• W2052572242 cites W2025713422 @default.
• W2052572242 cites W2026371597 @default.
• W2052572242 cites W2045777437 @default.
• W2052572242 cites W2049846676 @default.
• W2052572242 cites W2050545911 @default.
• W2052572242 cites W2054454491 @default.
• W2052572242 cites W2056382126 @default.
• W2052572242 cites W2063337177 @default.
• W2052572242 cites W2074450640 @default.
• W2052572242 cites W2081459419 @default.
• W2052572242 cites W2084502634 @default.
• W2052572242 cites W2084890307 @default.
• W2052572242 cites W2087511403 @default.
• W2052572242 cites W2095457746 @default.
• W2052572242 cites W2096165302 @default.
• W2052572242 cites W2098586307 @default.
• W2052572242 cites W2098848671 @default.
• W2052572242 cites W2100225664 @default.
• W2052572242 cites W2104162045 @default.
• W2052572242 cites W2106521012 @default.
• W2052572242 cites W2112007824 @default.
• W2052572242 cites W2113239879 @default.
• W2052572242 cites W2117837506 @default.
• W2052572242 cites W2139732486 @default.
• W2052572242 cites W2141224615 @default.
• W2052572242 cites W2142929121 @default.
• W2052572242 cites W2168916526 @default.
• W2052572242 cites W2182830251 @default.
• W2052572242 cites W2285972583 @default.
• W2052572242 cites W2344172918 @default.
• W2052572242 cites W2404964860 @default.
• W2052572242 cites W2411833749 @default.
• W2052572242 cites W2506687088 @default.
• W2052572242 cites W2618472358 @default.
• W2052572242 cites W3111785144 @default.
• W2052572242 cites W3141270700 @default.
• W2052572242 cites W397638970 @default.
• W2052572242 doi "https://doi.org/10.1016/s1472-6483(10)60050-8" @default.
• W2052572242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3015149" @default.
• W2052572242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19573295" @default.
• W2052572242 hasPublicationYear "2009" @default.
• W2052572242 type Work @default.
• W2052572242 sameAs 2052572242 @default.
• W2052572242 citedByCount "5" @default.
• W2052572242 countsByYear W20525722422013 @default.
• W2052572242 countsByYear W20525722422020 @default.
• W2052572242 crossrefType "journal-article" @default.
• W2052572242 hasAuthorship W2052572242A5031626342 @default.
• W2052572242 hasAuthorship W2052572242A5047168197 @default.
• W2052572242 hasAuthorship W2052572242A5050479075 @default.
• W2052572242 hasAuthorship W2052572242A5077397169 @default.
• W2052572242 hasBestOaLocation W20525722421 @default.
• W2052572242 hasConcept C104317684 @default.
• W2052572242 hasConcept C120763696 @default.
• W2052572242 hasConcept C127716648 @default.
• W2052572242 hasConcept C135763542 @default.
• W2052572242 hasConcept C16685009 @default.
• W2052572242 hasConcept C181199279 @default.
• W2052572242 hasConcept C196843134 @default.
• W2052572242 hasConcept C2777318727 @default.
• W2052572242 hasConcept C54355233 @default.
• W2052572242 hasConcept C55493867 @default.
• W2052572242 hasConcept C71924100 @default.
• W2052572242 hasConcept C86803240 @default.
• W2052572242 hasConcept C87073359 @default.
• W2052572242 hasConcept C88099638 @default.

• next