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- W2052576278 abstract "Emerging evidence indicates that signaling between perisynaptic astrocytes and neurons at the tripartite synapse plays an important role during the critical period when neural circuits are formed and refined. Cross-talk between astrocytes and neurons during development mediates synaptogenesis, synapse elimination and structural plasticity through a variety of secreted and contact-dependent signals. Recent live imaging studies reveal a dynamic and cooperative interplay between astrocytes and neurons at synapses that is guided by a variety of molecular cues. A unifying theme from these recent findings is that astrocytes can promote the development and plasticity of synaptic circuits. Insight into the molecular mechanisms by which astrocytes regulate the wiring of the brain during development could lead to new therapeutic strategies to promote repair and rewiring of neural circuits in the mature brain following CNS injury and neurodegenerative disease." @default.
- W2052576278 created "2016-06-24" @default.
- W2052576278 creator A5019182420 @default.
- W2052576278 date "2008-01-01" @default.
- W2052576278 modified "2023-10-18" @default.
- W2052576278 title "Neuron-Astrocyte Signaling in the Development and Plasticity of Neural Circuits" @default.
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- W2052576278 doi "https://doi.org/10.1159/000123038" @default.
- W2052576278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18635944" @default.
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