Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052584610> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2052584610 endingPage "694" @default.
- W2052584610 startingPage "687" @default.
- W2052584610 abstract "Retroposable elements such as retroviral and lentiviral vectors have been employed for many gene therapy applications. Unfortunately, such gene transfer vectors integrate genes into many different DNA sequences and unintended integration of the vector near a growth-promoting gene can engender pathological consequences. For example, retroviral vector-mediated gene transfer induced leukemia in 2 of 11 children treated for severe combined immunodeficiency, raising significant safety issues for gene transfer strategies that cannot be targeted to specific sequences. Here, we examine the use of a mobile retroposable genetic element that can be targeted to introduce therapeutic sequences site specifically into mutant genes. The data demonstrate that the mobile group II intron from Lactococcus lactis can be targeted to insert into and repair mutant lacZ (approved gene symbol GLB1) and beta-globin (approved gene symbol HBB) genes with high efficiency and fidelity in model systems in bacteria. These results suggest that these mobile genetic elements represent a novel class of agents for performing targeted genetic repair." @default.
- W2052584610 created "2016-06-24" @default.
- W2052584610 creator A5005988075 @default.
- W2052584610 creator A5040370918 @default.
- W2052584610 creator A5047364069 @default.
- W2052584610 creator A5077545337 @default.
- W2052584610 creator A5082990987 @default.
- W2052584610 creator A5085199809 @default.
- W2052584610 date "2005-05-01" @default.
- W2052584610 modified "2023-09-25" @default.
- W2052584610 title "Retargeting mobile group II introns to repair mutant genes" @default.
- W2052584610 cites W1592445034 @default.
- W2052584610 cites W1840552006 @default.
- W2052584610 cites W1977335029 @default.
- W2052584610 cites W1980888760 @default.
- W2052584610 cites W1992778012 @default.
- W2052584610 cites W2007099197 @default.
- W2052584610 cites W2010104346 @default.
- W2052584610 cites W2012821943 @default.
- W2052584610 cites W2020887273 @default.
- W2052584610 cites W2022449135 @default.
- W2052584610 cites W2042841971 @default.
- W2052584610 cites W2045901895 @default.
- W2052584610 cites W2050908220 @default.
- W2052584610 cites W2050992506 @default.
- W2052584610 cites W2053191459 @default.
- W2052584610 cites W2060576378 @default.
- W2052584610 cites W2073263035 @default.
- W2052584610 cites W2086105540 @default.
- W2052584610 cites W2102575752 @default.
- W2052584610 cites W2142639875 @default.
- W2052584610 cites W2155089348 @default.
- W2052584610 cites W2176375858 @default.
- W2052584610 cites W2323613689 @default.
- W2052584610 cites W2332948280 @default.
- W2052584610 doi "https://doi.org/10.1016/j.ymthe.2005.01.014" @default.
- W2052584610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15851007" @default.
- W2052584610 hasPublicationYear "2005" @default.
- W2052584610 type Work @default.
- W2052584610 sameAs 2052584610 @default.
- W2052584610 citedByCount "26" @default.
- W2052584610 countsByYear W20525846102012 @default.
- W2052584610 countsByYear W20525846102014 @default.
- W2052584610 countsByYear W20525846102015 @default.
- W2052584610 countsByYear W20525846102017 @default.
- W2052584610 countsByYear W20525846102019 @default.
- W2052584610 countsByYear W20525846102020 @default.
- W2052584610 crossrefType "journal-article" @default.
- W2052584610 hasAuthorship W2052584610A5005988075 @default.
- W2052584610 hasAuthorship W2052584610A5040370918 @default.
- W2052584610 hasAuthorship W2052584610A5047364069 @default.
- W2052584610 hasAuthorship W2052584610A5077545337 @default.
- W2052584610 hasAuthorship W2052584610A5082990987 @default.
- W2052584610 hasAuthorship W2052584610A5085199809 @default.
- W2052584610 hasBestOaLocation W20525846101 @default.
- W2052584610 hasConcept C104317684 @default.
- W2052584610 hasConcept C111599444 @default.
- W2052584610 hasConcept C143065580 @default.
- W2052584610 hasConcept C54355233 @default.
- W2052584610 hasConcept C70721500 @default.
- W2052584610 hasConcept C86803240 @default.
- W2052584610 hasConceptScore W2052584610C104317684 @default.
- W2052584610 hasConceptScore W2052584610C111599444 @default.
- W2052584610 hasConceptScore W2052584610C143065580 @default.
- W2052584610 hasConceptScore W2052584610C54355233 @default.
- W2052584610 hasConceptScore W2052584610C70721500 @default.
- W2052584610 hasConceptScore W2052584610C86803240 @default.
- W2052584610 hasIssue "5" @default.
- W2052584610 hasLocation W20525846101 @default.
- W2052584610 hasLocation W20525846102 @default.
- W2052584610 hasOpenAccess W2052584610 @default.
- W2052584610 hasPrimaryLocation W20525846101 @default.
- W2052584610 hasRelatedWork W2002128513 @default.
- W2052584610 hasRelatedWork W2064207257 @default.
- W2052584610 hasRelatedWork W2117110650 @default.
- W2052584610 hasRelatedWork W2128665526 @default.
- W2052584610 hasRelatedWork W2156423843 @default.
- W2052584610 hasRelatedWork W2156674132 @default.
- W2052584610 hasRelatedWork W2171277769 @default.
- W2052584610 hasRelatedWork W4246662077 @default.
- W2052584610 hasRelatedWork W4247436401 @default.
- W2052584610 hasRelatedWork W2092874662 @default.
- W2052584610 hasVolume "11" @default.
- W2052584610 isParatext "false" @default.
- W2052584610 isRetracted "false" @default.
- W2052584610 magId "2052584610" @default.
- W2052584610 workType "article" @default.