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- W2052589062 abstract "Two naturally occurring chrondogenesis inducing peptides have been purified to homogeneity from demineralized bovine bone. Cartilage-inducing factors A and B are the bone-derived equivalents of transforming growth factor-beta types I and II. Both peptides exhibit identical biological activities in chondrogenesis assays and stimulate anchorage independent cell growth. In this study we show that both bone-derived factors are potent (ng/ml) inhibitors of both DNA synthesis and the anchorage independent growth of a variety of human and non-human tumor cells. Unique in this study is also a comparison of the activities of these polypeptide growth factors with recombinant transforming growth factor type I expressed in mammalian cells." @default.
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- W2052589062 date "1987-10-01" @default.
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- W2052589062 title "Bone-derived and recombinant transforming growth factor β′S are potent inhibitors of tumor cell growth" @default.
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- W2052589062 doi "https://doi.org/10.1016/0006-291x(87)90944-2" @default.
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