FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052590131> ?p ?o ?g. }

• W2052590131 endingPage "490" @default.
• W2052590131 startingPage "485" @default.
• W2052590131 abstract "Leptin levels are elevated in obese humans. Several studies have shown an association between hyperleptinemia and development of atherosclerosis and cardiovascular disease (CVD), but the relationship between leptin and vascular function remains unclear.To evaluate associations between circulating plasma leptin and measures of vascular function in a large sample of elderly individuals from the community.This cross-sectional study included 1016 subjects aged 70 (50% women) from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). The invasive technique forearm plethysmography with intra-arterial infusions of acetylcholine and sodium nitroprusside was used for estimation of endothelial dependent vasodilatation (EDV) and endothelial independent vasodilatation (EIDV), respectively, in resistance arteries, and the non-invasive technique ultrasound assessed flow mediated vasodilation (FMD) in conduit arteries. The aortic augmentation index (AoAI), a surrogate measure of arterial stiffness, was evaluated by pulse wave analysis. Associations of vascular function, arterial stiffness and blood pressure with leptin were explored.In sex-adjusted models, high levels of leptin were inversely associated with EDV and EIDV. These associations remained after stratification for sex, traditional risk factors of CVD and insulin resistance, but were attenuated after taking a measure of obesity (body mass index) into account. In addition, leptin associated with arterial stiffness and systolic and diastolic blood pressure.Hyperleptinemia associated inversely with vasodilatation in resistance arteries. Furthermore, hyperleptinemia associated with arterial stiffness and hypertension. These associations were attenuated after adjusting for body mass index suggesting that leptin may be the mediator between obesity and impaired vascular function." @default.
• W2052590131 created "2016-06-24" @default.
• W2052590131 creator A5015851170 @default.
• W2052590131 creator A5076809608 @default.
• W2052590131 creator A5084981229 @default.
• W2052590131 date "2013-06-01" @default.
• W2052590131 modified "2023-10-13" @default.
• W2052590131 title "Leptin and endothelial function in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study" @default.
• W2052590131 cites W102714011 @default.
• W2052590131 cites W1555489744 @default.
• W2052590131 cites W180933214 @default.
• W2052590131 cites W1963553242 @default.
• W2052590131 cites W1967054491 @default.
• W2052590131 cites W1978955123 @default.
• W2052590131 cites W1980445357 @default.
• W2052590131 cites W1999899896 @default.
• W2052590131 cites W2020556466 @default.
• W2052590131 cites W2041293047 @default.
• W2052590131 cites W2045965545 @default.
• W2052590131 cites W2066442598 @default.
• W2052590131 cites W2072206476 @default.
• W2052590131 cites W2089753905 @default.
• W2052590131 cites W2091181219 @default.
• W2052590131 cites W2097090662 @default.
• W2052590131 cites W2097184485 @default.
• W2052590131 cites W2109145238 @default.
• W2052590131 cites W2115655519 @default.
• W2052590131 cites W2122796015 @default.
• W2052590131 cites W2126090408 @default.
• W2052590131 cites W2129275176 @default.
• W2052590131 cites W2136634210 @default.
• W2052590131 cites W2138102988 @default.
• W2052590131 cites W2138599454 @default.
• W2052590131 cites W2141976211 @default.
• W2052590131 cites W2150966205 @default.
• W2052590131 cites W2153802091 @default.
• W2052590131 cites W2154964123 @default.
• W2052590131 cites W2164817600 @default.
• W2052590131 cites W2165884492 @default.
• W2052590131 cites W2168105134 @default.
• W2052590131 cites W2320210764 @default.
• W2052590131 cites W23573153 @default.
• W2052590131 doi "https://doi.org/10.1016/j.atherosclerosis.2013.03.018" @default.
• W2052590131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23591414" @default.
• W2052590131 hasPublicationYear "2013" @default.
• W2052590131 type Work @default.
• W2052590131 sameAs 2052590131 @default.
• W2052590131 citedByCount "39" @default.
• W2052590131 countsByYear W20525901312014 @default.
• W2052590131 countsByYear W20525901312015 @default.
• W2052590131 countsByYear W20525901312016 @default.
• W2052590131 countsByYear W20525901312017 @default.
• W2052590131 countsByYear W20525901312018 @default.
• W2052590131 countsByYear W20525901312019 @default.
• W2052590131 countsByYear W20525901312020 @default.
• W2052590131 countsByYear W20525901312021 @default.
• W2052590131 countsByYear W20525901312022 @default.
• W2052590131 countsByYear W20525901312023 @default.
• W2052590131 crossrefType "journal-article" @default.
• W2052590131 hasAuthorship W2052590131A5015851170 @default.
• W2052590131 hasAuthorship W2052590131A5076809608 @default.
• W2052590131 hasAuthorship W2052590131A5084981229 @default.
• W2052590131 hasConcept C120770815 @default.
• W2052590131 hasConcept C126322002 @default.
• W2052590131 hasConcept C134018914 @default.
• W2052590131 hasConcept C164705383 @default.
• W2052590131 hasConcept C17140001 @default.
• W2052590131 hasConcept C2775850156 @default.
• W2052590131 hasConcept C2777391703 @default.
• W2052590131 hasConcept C2779610285 @default.
• W2052590131 hasConcept C2780221984 @default.
• W2052590131 hasConcept C2780613262 @default.
• W2052590131 hasConcept C2780972559 @default.
• W2052590131 hasConcept C511355011 @default.
• W2052590131 hasConcept C519581460 @default.
• W2052590131 hasConcept C58245268 @default.
• W2052590131 hasConcept C71924100 @default.
• W2052590131 hasConcept C84393581 @default.
• W2052590131 hasConceptScore W2052590131C120770815 @default.
• W2052590131 hasConceptScore W2052590131C126322002 @default.
• W2052590131 hasConceptScore W2052590131C134018914 @default.
• W2052590131 hasConceptScore W2052590131C164705383 @default.
• W2052590131 hasConceptScore W2052590131C17140001 @default.
• W2052590131 hasConceptScore W2052590131C2775850156 @default.
• W2052590131 hasConceptScore W2052590131C2777391703 @default.
• W2052590131 hasConceptScore W2052590131C2779610285 @default.
• W2052590131 hasConceptScore W2052590131C2780221984 @default.
• W2052590131 hasConceptScore W2052590131C2780613262 @default.
• W2052590131 hasConceptScore W2052590131C2780972559 @default.
• W2052590131 hasConceptScore W2052590131C511355011 @default.
• W2052590131 hasConceptScore W2052590131C519581460 @default.
• W2052590131 hasConceptScore W2052590131C58245268 @default.
• W2052590131 hasConceptScore W2052590131C71924100 @default.
• W2052590131 hasConceptScore W2052590131C84393581 @default.
• W2052590131 hasIssue "2" @default.
• W2052590131 hasLocation W20525901311 @default.
• W2052590131 hasLocation W20525901312 @default.
• W2052590131 hasOpenAccess W2052590131 @default.

• next