FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052593262> ?p ?o ?g. }

• W2052593262 endingPage "697" @default.
• W2052593262 startingPage "692" @default.
• W2052593262 abstract "Human immunodeficiency virus-1 (HIV-1)–specific cytotoxic T-lymphocyte (CTL) responses are common in infected adults and usually exhibit rapid decay after combination antiretroviral therapy (ART). CTLs develop later in the first year of life, and the fate of HIV-1–specific responses in perinatally infected children after ART is less well described. HIV-1–specific CTL responses were measured in 17 perinatally infected children and adolescents (ages 3–20 y) receiving combination ART. Seven had prolonged viral suppression (<400 copies/mL) for 2.5–5.3 y and 10 had persistent viremia (median, 77,550 copies/mL). HIV-1–specific CTL responses were tested by interferon (IFN)-γ enzyme-linked immunospot (ELISpot) assays using 53 overlapping peptide pools spanning the entire HIV-1 proteome. HIV-1–specific CTL responses were detected in 14 of 17 individuals. Responses to one to four viral proteins were found in eight of 10 individuals with persistent viremia and six of seven with prolonged viral suppression. The magnitude and breadth of CTL responses were similar between groups. HIV-1–specific CTL responses were present in the majority of perinatally infected subjects, irrespective of viremia at evaluation. Because ART-treated infected adults usually have rapid decay of responses, these data suggest viral replication below the limits of detection is more persistent in combination ART-treated perinatally infected pediatric subjects. The long-term clinical implications of these findings remain to be determined." @default.
• W2052593262 created "2016-06-24" @default.
• W2052593262 creator A5008280183 @default.
• W2052593262 creator A5021889678 @default.
• W2052593262 creator A5027976940 @default.
• W2052593262 creator A5045734646 @default.
• W2052593262 creator A5050035326 @default.
• W2052593262 creator A5062526829 @default.
• W2052593262 creator A5088750296 @default.
• W2052593262 date "2007-06-01" @default.
• W2052593262 modified "2023-10-10" @default.
• W2052593262 title "Pediatric HIV-1–Specific Cytotoxic T-Lymphocyte Responses Suggesting Ongoing Viral Replication Despite Combination Antiretroviral Therapy" @default.
• W2052593262 cites W1490833013 @default.
• W2052593262 cites W1497870368 @default.
• W2052593262 cites W1549637102 @default.
• W2052593262 cites W1655510925 @default.
• W2052593262 cites W2006420804 @default.
• W2052593262 cites W2013320564 @default.
• W2052593262 cites W2028099639 @default.
• W2052593262 cites W2030844138 @default.
• W2052593262 cites W2053719303 @default.
• W2052593262 cites W2068461665 @default.
• W2052593262 cites W2075044148 @default.
• W2052593262 cites W2086104438 @default.
• W2052593262 cites W2096220246 @default.
• W2052593262 cites W2100740302 @default.
• W2052593262 cites W2100945419 @default.
• W2052593262 cites W2103182811 @default.
• W2052593262 cites W2103288295 @default.
• W2052593262 cites W2124969212 @default.
• W2052593262 cites W2126156212 @default.
• W2052593262 cites W2127281298 @default.
• W2052593262 cites W2127344222 @default.
• W2052593262 cites W2137901778 @default.
• W2052593262 cites W2139257243 @default.
• W2052593262 cites W2141345451 @default.
• W2052593262 cites W2144882745 @default.
• W2052593262 cites W2151303894 @default.
• W2052593262 cites W2151651155 @default.
• W2052593262 cites W2152908683 @default.
• W2052593262 cites W2156110652 @default.
• W2052593262 cites W2161134901 @default.
• W2052593262 cites W2161207924 @default.
• W2052593262 cites W2171820402 @default.
• W2052593262 cites W2172023022 @default.
• W2052593262 cites W2312499014 @default.
• W2052593262 cites W2319657764 @default.
• W2052593262 cites W2339173512 @default.
• W2052593262 doi "https://doi.org/10.1203/pdr.0b013e31805365ef" @default.
• W2052593262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17426646" @default.
• W2052593262 hasPublicationYear "2007" @default.
• W2052593262 type Work @default.
• W2052593262 sameAs 2052593262 @default.
• W2052593262 citedByCount "9" @default.
• W2052593262 countsByYear W20525932622016 @default.
• W2052593262 countsByYear W20525932622017 @default.
• W2052593262 countsByYear W20525932622020 @default.
• W2052593262 countsByYear W20525932622023 @default.
• W2052593262 crossrefType "journal-article" @default.
• W2052593262 hasAuthorship W2052593262A5008280183 @default.
• W2052593262 hasAuthorship W2052593262A5021889678 @default.
• W2052593262 hasAuthorship W2052593262A5027976940 @default.
• W2052593262 hasAuthorship W2052593262A5045734646 @default.
• W2052593262 hasAuthorship W2052593262A5050035326 @default.
• W2052593262 hasAuthorship W2052593262A5062526829 @default.
• W2052593262 hasAuthorship W2052593262A5088750296 @default.
• W2052593262 hasBestOaLocation W20525932621 @default.
• W2052593262 hasConcept C140704245 @default.
• W2052593262 hasConcept C142462285 @default.
• W2052593262 hasConcept C147969180 @default.
• W2052593262 hasConcept C154317977 @default.
• W2052593262 hasConcept C159047783 @default.
• W2052593262 hasConcept C167672396 @default.
• W2052593262 hasConcept C202751555 @default.
• W2052593262 hasConcept C203014093 @default.
• W2052593262 hasConcept C2522874641 @default.
• W2052593262 hasConcept C2776090121 @default.
• W2052593262 hasConcept C2776185481 @default.
• W2052593262 hasConcept C2779053233 @default.
• W2052593262 hasConcept C55493867 @default.
• W2052593262 hasConcept C71924100 @default.
• W2052593262 hasConcept C86803240 @default.
• W2052593262 hasConcept C8891405 @default.
• W2052593262 hasConceptScore W2052593262C140704245 @default.
• W2052593262 hasConceptScore W2052593262C142462285 @default.
• W2052593262 hasConceptScore W2052593262C147969180 @default.
• W2052593262 hasConceptScore W2052593262C154317977 @default.
• W2052593262 hasConceptScore W2052593262C159047783 @default.
• W2052593262 hasConceptScore W2052593262C167672396 @default.
• W2052593262 hasConceptScore W2052593262C202751555 @default.
• W2052593262 hasConceptScore W2052593262C203014093 @default.
• W2052593262 hasConceptScore W2052593262C2522874641 @default.
• W2052593262 hasConceptScore W2052593262C2776090121 @default.
• W2052593262 hasConceptScore W2052593262C2776185481 @default.
• W2052593262 hasConceptScore W2052593262C2779053233 @default.
• W2052593262 hasConceptScore W2052593262C55493867 @default.
• W2052593262 hasConceptScore W2052593262C71924100 @default.
• W2052593262 hasConceptScore W2052593262C86803240 @default.

• next