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• W2052599518 abstract "Polarization of the mitochondrial membrane potential (ΔΨm) is critical for normal mitochondrial function and cellular energetics. Mitochondrial dysfunction, manifesting as disrupted ΔΨm polarization (i.e. depolarization or hyperpolarization), underlies several important and highly prevalent diseases, including a variety of cardiac and neurological disorders. As such, ΔΨm instability might form a unifying mechanism for a class of metabolic disorders affecting excitable tissues. Here, we measured the spatio-temporal kinetics of ΔΨm changes across the intact heart using high-resolution optical ΔΨm imaging and uncovered surprisingly complex spatial patterns and dynamically fluctuating changes in ΔΨm that developed into actively propagating waves of mitochondrial depolarization during global ischemia. Our data further indicated that the recovery of ΔΨm upon reperfusion is dictated by the duration of the preceding ischemic insult. Post-ischemic electrical and functional recovery was dependent on early ΔΨm recovery but independent of overall cellular injury measured using a standard assay of lactate dehydrogenase release. These findings reveal a novel mechanism by which instabilities in cellular energetic properties that are independent of irreversible cellular injury can scale to the level of the intact organ via an organized process of active conduction involving the multi-cellular network. This highlights the importance of investigating cellular metabolic properties in the context of the intact organ." @default.
• W2052599518 created "2016-06-24" @default.
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• W2052599518 date "2010-10-01" @default.
• W2052599518 modified "2023-10-12" @default.
• W2052599518 title "Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart" @default.
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• W2052599518 doi "https://doi.org/10.1016/j.yjmcc.2010.07.002" @default.
• W2052599518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081287" @default.
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