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- W2052606181 abstract "AllergyVolume 39, Issue 8 p. 565-571 Ciclosporin (Cyclosporin A): Prototype of a New Generation of Immunosuppressive Drugs K. Bendtzen, Corresponding Author K. Bendtzen Medical Department TA, The State University Hospital, Copenhagen, DenmarkAddress: Klaus Bendtzen, Medical Department TA, University Hospital of Copenhagen, Tagensvej 20, DK-2200 Copenhagen N, DenmarkSearch for more papers by this author K. Bendtzen, Corresponding Author K. Bendtzen Medical Department TA, The State University Hospital, Copenhagen, DenmarkAddress: Klaus Bendtzen, Medical Department TA, University Hospital of Copenhagen, Tagensvej 20, DK-2200 Copenhagen N, DenmarkSearch for more papers by this author First published: November 1984 https://doi.org/10.1111/j.1398-9995.1984.tb01976.xCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Attallah, A. M., Urritia-Shaw, A., Yeatman, T. J. & Folks, T.: Effect of the new immunosuppressive agent cyclosporin-A on natural killer cell and antibody-dependent cell-mediated cytotoxic activity. Int. Arch. Allergy Appl. Immunol. 65, 465–469, 1981. 2 Baldwin, W. M., Hutchinson, I. F., Meijer, C. J. L. M. & Tilney, N. L.: Immune responses to organ allografts. III. 18. Marked decrease in medullary thymocytes and splenic T lymphocytes after cyclosporin A treatment. Transplantation 31, 117–120, 1981. 3 Bendtzen, K.: Induction of antigen-specific lymphocyte unresponsiveness in vitro: Possible role of divalent cations and defective function of human T-cell-activating factor (TAF). Cell. Immunol. 66, 152–163, 1982. 4 Bendtzen, K.: Biological properties of interleukins. Allergy 38, 219–226, 1983. 5 Bendtzen, K. & Dinarello, C. A.: Mechanism of action of cyclosporin A. Effect on T-cell-binding of interleukin 1 and antagonizing effect of insulin. Scand. J. Immunol. 20, 43–51, 1984. 6 Bendtzen, K. & Petersen, J.: Effects of cyclosporin A (CyA) and methylprednisolone (MP) on the immune response. I. T-cell-activating factor (IL-1) abrogates CyA- but not MP-induced suppression of antigen-induced lymphokine production. Immunol. Lett. 5, 79–83, 1982. 7 Bendtzen, K. & Petersen, J.: Effect of cyclosporin A (CyA) on the immune response. CyA competitively inhibits the function of monocyte/macrophage-derived T lymphocyte-activating factor(s). Immunol. Lett. 5, 331–336, 1982. 8 Bendtzen, K., Petersen, J. & Soeberg, B.: Effects of 24. cyclosporin A (CyA) and methylprednisolone (MP) on the immune response. II. Further studies of the monocyte - T cell interactions leading to iymphokine production. Acta Pathol. Microbiol. Immunol. Scand. [C] 91, 159–168, 1983. 9 Bendtzen, K. & Thomsen, M.: The T cell suppressive function of cyclosporin A is counteracted by insulin. IRCS Med. Sci. 12, 280–281, 1984. 10 Bendtzen, K., Tvede, N., Andersen, V. & Bendixen, G.: Cyclosporin for polymyositis. Lancet 1, 792–793, 1984. 11 Bird, A. G., McLachlan, S. M. & Britton, S.: Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein- Barr virus-induced B-cell lines. Nature 289, 300–301, 1981. 12 Borel, J. F.: The history of cyclosporin A and its significance. In D. J. G. White, (ed.): Cyclosporin A, pp. 5–17, Elsevier Biomedical Press, Amsterdam , 1982. 13 Borel, J. F., Feurer, C., Gubler, H. U. & Stähelin, H.: Biological effects of cyclosporin A: A new antilymphocytic agent. Agents Actions 6/4, 468–475, 1976. 14 Borel, J. F., Feurer, C., Magnee, C. & Stähelin, H.: Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 32, 1017–1027, 1977. 15 Britton, S. & Palacios, R.: Cyclosporin A - Usefulness risks and mechanism of action. Immunol. Rev. 65, 5–22, 1982. 16 Bunjes, D., Hardt, C., Röllinghoff, M. & Wagner, H.: Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2. Eur. J. Immunol. 11, 657–661, 1981. 17 Calne, R. Y., White, D. J. G., Thiru, S., et al.: Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 2, 1323–1327, 1978. 18 Canadian Multicentre Transplant Study Group: A randomized clinical trial of cyclosporine in cadaveric renal transplantation. N. Engl. J. Med. 309, 809–815, 1983. 19 European Multicentre Trial Group: Cyclosporin in cadaveric renal transplantation: One-year follow-up of a multicentre trial. Lancet 2, 986–989, 1983. 20 Graf, U., Marbet, U., Müller, W. & Thiel, G.: Cyclosporin A – Wirkungen und nebenwirkungen bei der behandlung der chronischen polyarthritis und der psoriasisarthritis. Immunol. Infekt. 9, 20–28, 1981. 21 Helderman, J. H., Reynolds, T. C. & Strom, T. B.: The insulin receptor as a universal marker of activated lymphocytes. Eur. J. Immunol. 8, 589–595, 1978. 22 Hess, A. D. & Tutschka, P. J.: Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR. J. Immunol. 124, 2601–2608, 1980. 23 Hess, A. D., Tutschka, P. J., Pu, Z. & Santos, G. W.: Effect of cyclosporin A on human lymphocyte responses in vitro. IV. Production of T cell stimulatory growth factors and development of responsiveness to these growth factors in CsA-treated primary MLR cultures. J. J. Immunol. 128, 360–367, 1982. 24 Hess, A. D., Tutschka, P. J. & Santos, G. W.: Effect of cyclosporin A on human lymphocyte responses in vitro. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell. J. Immunol. 126, 961–968, 1981. 25 Hutchinson, I. F., Shadur, C. A., Duarte, J. S. A., Strom, T. B. & Tilney, N. L.: Cyclosporin A spares selectively lymphocytes with donor-specific suppressor characteristics. Transplantation 32, 210–216, 1981. 26 Isenberg, D. A., Snaith, M. L., Morrow, W. J. W., el al.: Cyclosporin A for the treatment of systemic lupus erythematosus. Int. J. Immunopharmacol. 3, 163–165, 1981. 27 Jamieson, S. W., Reitz, B. A., Oyer, P. E., et al.: Combined heart and lung transplantation. Lancet 1, 1130–1132, 1983. 28 Kharazmi, A., Svenson, M., Nielsen, H. & Birgens, H. S.: Effect of cyclosporin A on human neutrophil and monocyte function. Immunology (submitted). 29 Kostakis, A. J., White, D. J. G. & Calne, R. Y.: Prolongation of rat heart allograft survival by cyclosporin A. IRCS Med. Sci. 5, 280, 1977. 30 Larsson, E. L.: Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process. J. Immunol. 124, 2828–2833, 1980. 31 Laupacis, A., Stiller, C. R., Gardell, C., et al.: Cyclosporin prevents diabetes in BB Wistar rats. Lancet 1, 10–11, 1983. 32 LeGrue, S. J., Friedman, A. W. & Kahan, B. D.: Binding of cyclosporine by human lymphocytes and phospholipid vesicles. J. Immunol. 131, 712–718, 1983. 33 Mann, D. L., Mendell, N., Kahn, C. R. & Johnson, A. H.: In vitro lymphocyte proliferation response to therapeutic insulin components. J. Clin. Invest. 72, 1130–1138, 1983. 34 Müller-Hermelink, H. K., Kaiserling, E. & Sonntag, H. G.: Modulation of epithelioid cell granuloma formation to apathogenic mycobacteria by cyclosporin A. Pathol. Res. Pract. 175, 80–96, 1982. 35 Muraguchi, A., Butler, J. L., Kehrl, J. H., Falkoff, R. J. M. & Fauci, A. S.: Selective suppression of an early step in human B cell activation by cyclosporin A. J. Exp. Med. 158, 690–702, 1983. 36 Nickell, S. P., Scheibel, L. W. & Cole, G. A.: Inhibition by cyclosporin A of rodent malaria in vivo and human malaria in vitro. Inf. Immunity 37, 1093–1100, 1982. 37 Nussenblatt, R. B., Rook, A. H., Wacker, W. B., Palestine, A. G., Scher, I. & Gery, I.: Treatment of intraocular inflammatory disease with cyclosporin A. Lancet 2, 235–238, 1983. 38 Palacios, R. & Möller, G.: Cyclosporin A blocks receptors for HLA-DR antigens on T cells. Nature 290, 792–794, 1981. 39 Pedersen, C., Permin, H., Skov, P. S., et al.: Inhibitory effect of cyclosporin A on histamine release from human leukocytes and rat mast cells. Allergy (In press). 40 Powles, R. L., Barrett, A. J., Clink, H. M., Kay, H. E. M., Sloane, J. & McElwain, T. J.: Cyclosporin A for the treatment of graft-versus-host disease in man. Lancet 2, 1327–1331, 1978. 41 Puttick, L., Pollock, A. & Fairburn, E.: Treatment of Sezary syndrome with cyclosporin A. J. R. Soc. Med. 76, 1063–1065, 1983. 42 Rebuck, A. S., Stiller, C. R., Braude, A. C., Laupacis, A., Cohen, R. D. & Chapman, K. R.: Cyclosporin for pulmonary sarcoidosis. Lancet 1, 1174, 1984. 43 Ryffel, B., Götz, U. & Heuberger, B.: Cyclosporin receptors on human lymphocytes. J. Immunol. 129, 1978–1982, 1982. 44 Schlossman, S. F., Meuer, S. C., Acuto, O., Morimoto, C. & Reinherz, E. L.: Human T lymphocytes: Their differentiative history and functional program. Progr. Immunol. 5, 1069–1078, 1983. 45 Starzl, T. E., Klintmalm, G. B. G., Porter, K. A., Iwatsuki, S. & Schröter, G. P. J.: Liver transplantation with use of cyclosporin A and prednisone. N. Engl. J. Med. 305, 266–269, 1981. 46 Starzl, T. E., Porter, K. A., Iwatsuki, S., et al.: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1, 583–587, 1984. 47 Stiller, C. R., Dupre, J., Gent, M., et al.: Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 223, 1362–1367, 1984. 48 Stryckmans, P. A., Dumont, J. P., Velu, T. & Debus-scher, L.: Cyclosporine in refractory severe a plastic anemia. N. Engl. J. Med. 310, 655–656, 1984. 49 Thomas, H. C., Routhier, G., Epstein, O., Goldstein, G., Janossy, G. & Sherlock, S.: Cyclosporin A in primary biliary cirrhosis. Gastroenterology 79, 1059, 1980. 50 Thomson, A. W.: Immunobiology of cyclosporin A. Aust. J. Exp. Biol. Med. Sci. 61, 147–172, 1983. 51 Tosato, G., Pike, S. E., Koski, I. R. & Blaese, R. M.: Selective inhibition of immunoregulatory cell functions by cyclosporin A. J. Immunol. 128, 1986–1991, 1982. 52 Wenger, R.: Chemistry of cyclosporin. In D. J. G. White, (ed.): Cyclosporin A, pp. 19–34, Elsevier Biomedical Press, Amsterdam , 1982. 53 White, D. J. G.: Cyclosporin A. Clinical pharmacology and therapeutic potential. Drugs 24, 322–334, 1982. 54 White, D. J. G. & Calne, R. Y.: The use of cyclosporin A immunosuppression in organ grafting. Immunol. Rev. 65, 115–131, 1982. 55 Zabel, P., Leimenstoll, G. & Gross, W. L.: Cyclosporin for acute dertnatomyositis. Lancet 1, 343-, 1984. Citing Literature Volume39, Issue8November 1984Pages 565-571 ReferencesRelatedInformation" @default.
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