FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052622304> ?p ?o ?g. }

• W2052622304 endingPage "139" @default.
• W2052622304 startingPage "129" @default.
• W2052622304 abstract "Curcumin (diferuloylmethane), a polyphenolic compound, is a component of Curcuma longa, commonly known as turmeric. It is a well-known anti-inflammatory, anti-oxidative, and anti-lipidemic agent and has recently been shown to modulate several diseases via epigenetic regulation. Many recent studies have demonstrated the role of epigenetic inactivation of pivotal genes that regulate human pathologies, such as neurocognitive disorders, inflammation, obesity, and cancers. Epigenetic changes involve changes in DNA methylation, histone modifications, or altered microRNA expression patterns which are known to be interconnected and play a key role in tumor progression and failure of conventional chemotherapy. The majority of epigenetic changes are influenced by lifestyle and diets. In this regard, dietary phytochemicals as dietary supplements have emerged as a promising source that are able to reverse these epigenetic alterations, to actively regulate gene expression and molecular targets that are known to promote tumorigenesis, and also to prevent age-related diseases through epigenetic modifications. There have been several studies which reported the role of curcumin as an epigenetic regulator in neurological disorders, inflammation, and in diabetes apart from cancers. The epigenetic regulatory roles of curcumin include (1) inhibition of DNA methyltransferases (DNMTs), which has been well defined from the recent studies on its function as a DNA hypomethylating agent; (2) regulation of histone modifications via regulation of histone acetyltransferases (HATs) and histone deacetylases (HDACs); and (3) regulation of micro RNAs (miRNA). This review summarizes the current knowledge on the effect of curcumin in the treatment and/or prevention of inflammation, neurodegenerative diseases, and cancers by regulating histone deacetylases, histone acetyltransferases, and DNA methyltransferases." @default.
• W2052622304 created "2016-06-24" @default.
• W2052622304 creator A5006840585 @default.
• W2052622304 creator A5032783205 @default.
• W2052622304 date "2015-04-01" @default.
• W2052622304 modified "2023-10-12" @default.
• W2052622304 title "“Curcumin, the King of Spices”: Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases" @default.
• W2052622304 cites W144423133 @default.
• W2052622304 cites W1604068141 @default.
• W2052622304 cites W1633851220 @default.
• W2052622304 cites W1832884666 @default.
• W2052622304 cites W1964575217 @default.
• W2052622304 cites W1968527707 @default.
• W2052622304 cites W1970174702 @default.
• W2052622304 cites W1976626368 @default.
• W2052622304 cites W1977679503 @default.
• W2052622304 cites W1990889144 @default.
• W2052622304 cites W1997149430 @default.
• W2052622304 cites W1997889012 @default.
• W2052622304 cites W1998849566 @default.
• W2052622304 cites W2002129512 @default.
• W2052622304 cites W2002995168 @default.
• W2052622304 cites W2004078197 @default.
• W2052622304 cites W2004142122 @default.
• W2052622304 cites W2006290358 @default.
• W2052622304 cites W2006787573 @default.
• W2052622304 cites W2007366502 @default.
• W2052622304 cites W2008665179 @default.
• W2052622304 cites W2009121506 @default.
• W2052622304 cites W2009163569 @default.
• W2052622304 cites W2010474330 @default.
• W2052622304 cites W2010720331 @default.
• W2052622304 cites W2014203415 @default.
• W2052622304 cites W2014442719 @default.
• W2052622304 cites W2014652912 @default.
• W2052622304 cites W2016264180 @default.
• W2052622304 cites W2018038176 @default.
• W2052622304 cites W2019887381 @default.
• W2052622304 cites W2029933341 @default.
• W2052622304 cites W2035308484 @default.
• W2052622304 cites W2038458062 @default.
• W2052622304 cites W2038624390 @default.
• W2052622304 cites W2039466736 @default.
• W2052622304 cites W2040257851 @default.
• W2052622304 cites W2044783100 @default.
• W2052622304 cites W2050587453 @default.
• W2052622304 cites W2059176821 @default.
• W2052622304 cites W2059960344 @default.
• W2052622304 cites W2060271784 @default.
• W2052622304 cites W2061428265 @default.
• W2052622304 cites W2064149487 @default.
• W2052622304 cites W2065481158 @default.
• W2052622304 cites W2068485963 @default.
• W2052622304 cites W2069696610 @default.
• W2052622304 cites W2069938271 @default.
• W2052622304 cites W2070942659 @default.
• W2052622304 cites W2071959081 @default.
• W2052622304 cites W2075799337 @default.
• W2052622304 cites W2084790890 @default.
• W2052622304 cites W2090054406 @default.
• W2052622304 cites W2090703365 @default.
• W2052622304 cites W2093382452 @default.
• W2052622304 cites W2096083625 @default.
• W2052622304 cites W2098912815 @default.
• W2052622304 cites W2100581810 @default.
• W2052622304 cites W2100932663 @default.
• W2052622304 cites W2101356736 @default.
• W2052622304 cites W2109164958 @default.
• W2052622304 cites W2112808742 @default.
• W2052622304 cites W2114368028 @default.
• W2052622304 cites W2116646376 @default.
• W2052622304 cites W2120208667 @default.
• W2052622304 cites W2127808743 @default.
• W2052622304 cites W2130176321 @default.
• W2052622304 cites W2133097250 @default.
• W2052622304 cites W2133410852 @default.
• W2052622304 cites W2134860537 @default.
• W2052622304 cites W2138471590 @default.
• W2052622304 cites W2142501544 @default.
• W2052622304 cites W2143820389 @default.
• W2052622304 cites W2144766684 @default.
• W2052622304 cites W2144792857 @default.
• W2052622304 cites W2147524392 @default.
• W2052622304 cites W2150536104 @default.
• W2052622304 cites W2152525883 @default.
• W2052622304 cites W2153106604 @default.
• W2052622304 cites W2156156861 @default.
• W2052622304 cites W2162685760 @default.
• W2052622304 cites W2166867774 @default.
• W2052622304 cites W2168584828 @default.
• W2052622304 cites W2168829937 @default.
• W2052622304 cites W2171439919 @default.
• W2052622304 cites W2597632520 @default.
• W2052622304 cites W788622 @default.
• W2052622304 doi "https://doi.org/10.1007/s40495-015-0018-x" @default.
• W2052622304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4596544" @default.
• W2052622304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26457241" @default.
• W2052622304 hasPublicationYear "2015" @default.

• next