Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052623611> ?p ?o ?g. }
- W2052623611 endingPage "2185" @default.
- W2052623611 startingPage "2178" @default.
- W2052623611 abstract "Background Aging and chronic alcohol consumption are both modifiers of DNA methylation, but it is not yet known whether chronic alcohol consumption also alters DNA hydroxymethylation, a newly discovered epigenetic mark produced by oxidation of methylcytosine. Furthermore, it has not been tested whether aging and alcohol interact to modify this epigenetic phenomenon, thereby having an independent effect on gene expression. Methods Old (18 months) and young (4 months) male C57BL/6 mice were pair‐fed either a L ieber‐ D e C arli liquid diet with alcohol (18% of energy) or an isocaloric L ieber‐ D e C arli control diet for 5 weeks. Global DNA hydroxymethylation and DNA methylation were analyzed from hepatic DNA using a new liquid chromatography‐tandem mass spectrometry method. Hepatic m RNA expression of the T et enzymes were measured via quantitative real‐time polymerase chain reaction. Results In young mice, mild chronic alcohol exposure significantly reduced global DNA hydroxymethylation compared with control mice (0.22 ± 0.01 vs. 0.29 ± 0.06%, p = 0.004). Alcohol did not significantly alter hydroxymethylcytosine levels in old mice. Old mice fed the control diet showed decreased global DNA hydroxymethylation compared with young mice fed the control diet (0.24 ± 0.02 vs. 0.29 ± 0.06%, p = 0.04). This model suggests an interaction between aging and alcohol in determining DNA hydroxymethylation ( p interaction = 0.009). Expression of Tet2 and Tet3 was decreased in the old mice relative to the young ( p < 0.005). Conclusions The observation that alcohol alters DNA hydroxymethylation indicates a new epigenetic effect of alcohol. This is the first study demonstrating the interactive effects of chronic alcohol consumption and aging on DNA hydroxymethylation." @default.
- W2052623611 created "2016-06-24" @default.
- W2052623611 creator A5012768419 @default.
- W2052623611 creator A5022510637 @default.
- W2052623611 creator A5058290335 @default.
- W2052623611 creator A5063650307 @default.
- W2052623611 creator A5064408814 @default.
- W2052623611 creator A5089619265 @default.
- W2052623611 creator A5090030002 @default.
- W2052623611 date "2014-07-28" @default.
- W2052623611 modified "2023-10-06" @default.
- W2052623611 title "Aging and Alcohol Interact to Alter Hepatic DNA Hydroxymethylation" @default.
- W2052623611 cites W1486257535 @default.
- W2052623611 cites W1491419518 @default.
- W2052623611 cites W1492600479 @default.
- W2052623611 cites W1582406013 @default.
- W2052623611 cites W1597628009 @default.
- W2052623611 cites W1976703831 @default.
- W2052623611 cites W1981463058 @default.
- W2052623611 cites W1990689143 @default.
- W2052623611 cites W1997678698 @default.
- W2052623611 cites W1999659629 @default.
- W2052623611 cites W2004078197 @default.
- W2052623611 cites W2008861148 @default.
- W2052623611 cites W2026255880 @default.
- W2052623611 cites W2030406772 @default.
- W2052623611 cites W2033433026 @default.
- W2052623611 cites W2038756976 @default.
- W2052623611 cites W2040183742 @default.
- W2052623611 cites W2050354664 @default.
- W2052623611 cites W2053542703 @default.
- W2052623611 cites W2059099579 @default.
- W2052623611 cites W2069428487 @default.
- W2052623611 cites W2076011117 @default.
- W2052623611 cites W2079161657 @default.
- W2052623611 cites W2082806802 @default.
- W2052623611 cites W2084410329 @default.
- W2052623611 cites W2085745662 @default.
- W2052623611 cites W2093052345 @default.
- W2052623611 cites W2095203795 @default.
- W2052623611 cites W2097342705 @default.
- W2052623611 cites W2098979202 @default.
- W2052623611 cites W2100628640 @default.
- W2052623611 cites W2101173364 @default.
- W2052623611 cites W2101780023 @default.
- W2052623611 cites W2103486606 @default.
- W2052623611 cites W2108664872 @default.
- W2052623611 cites W2115936826 @default.
- W2052623611 cites W2121471393 @default.
- W2052623611 cites W2123831833 @default.
- W2052623611 cites W2124345456 @default.
- W2052623611 cites W2134466661 @default.
- W2052623611 cites W2136561166 @default.
- W2052623611 cites W2137983089 @default.
- W2052623611 cites W2143798330 @default.
- W2052623611 cites W2144458575 @default.
- W2052623611 cites W2144958191 @default.
- W2052623611 cites W2148337554 @default.
- W2052623611 cites W2149254097 @default.
- W2052623611 cites W2151566837 @default.
- W2052623611 cites W2161326542 @default.
- W2052623611 cites W4233379123 @default.
- W2052623611 doi "https://doi.org/10.1111/acer.12477" @default.
- W2052623611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146686" @default.
- W2052623611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25070523" @default.
- W2052623611 hasPublicationYear "2014" @default.
- W2052623611 type Work @default.
- W2052623611 sameAs 2052623611 @default.
- W2052623611 citedByCount "23" @default.
- W2052623611 countsByYear W20526236112014 @default.
- W2052623611 countsByYear W20526236112015 @default.
- W2052623611 countsByYear W20526236112016 @default.
- W2052623611 countsByYear W20526236112017 @default.
- W2052623611 countsByYear W20526236112018 @default.
- W2052623611 countsByYear W20526236112019 @default.
- W2052623611 countsByYear W20526236112020 @default.
- W2052623611 crossrefType "journal-article" @default.
- W2052623611 hasAuthorship W2052623611A5012768419 @default.
- W2052623611 hasAuthorship W2052623611A5022510637 @default.
- W2052623611 hasAuthorship W2052623611A5058290335 @default.
- W2052623611 hasAuthorship W2052623611A5063650307 @default.
- W2052623611 hasAuthorship W2052623611A5064408814 @default.
- W2052623611 hasAuthorship W2052623611A5089619265 @default.
- W2052623611 hasAuthorship W2052623611A5090030002 @default.
- W2052623611 hasBestOaLocation W20526236112 @default.
- W2052623611 hasConcept C104317684 @default.
- W2052623611 hasConcept C126322002 @default.
- W2052623611 hasConcept C134018914 @default.
- W2052623611 hasConcept C150194340 @default.
- W2052623611 hasConcept C153911025 @default.
- W2052623611 hasConcept C185592680 @default.
- W2052623611 hasConcept C190727270 @default.
- W2052623611 hasConcept C2778901553 @default.
- W2052623611 hasConcept C2781066024 @default.
- W2052623611 hasConcept C3019635848 @default.
- W2052623611 hasConcept C33288867 @default.
- W2052623611 hasConcept C41091548 @default.
- W2052623611 hasConcept C48023723 @default.