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- W2052626566 abstract "(1) Effect of flufenamic acid on hypotonie hemolysis of rat erythrocytes was investigated with special reference to temperature at which hemolysis took place. At low temperature such as 0 or 12°, flufenamic acid exhibited a dose-dependent inhibition of hemolysis at relatively low concentrations. This protective effect of flufenamic acid was, however, diminished by increase of temperature of hypotonie medium and finally it caused acceleration of hemolysis at 37°. Chlorpromazine was, in contrast with flufenamic acid, found to be protective at any temperature between 0 and 37°. (2) Flufenamic acid molecules were found to be adsorbed by rat erythrocyte either at 0 or 37°, but the manner of adsorption at 0° was quite different from adsorption at 37°. Kinetically, adsorption at 37° seems to be only passive, whereas some active bindingsites are assumed at the surface of erythrocyte membrane at 0°. (3) Effect on hypotonie hemolysis of a number of clinically useful drugs known as the membrane stabilizer were tested with respect to their temperature-dependency and they were found to be classified into two types; flufenamic acid type and chlorpromazine type. Drugs classified as the former were mostly acidic in the chemical nature and only anti-inflammatory drugs were found in this group. On the other hand, drugs of the latter were basic or non-ionic compounds and most of the tested tranquilizers, antihistamines, local anesthetics and non-ionic anti-inflammatory drugs belonged to this group." @default.
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- W2052626566 date "1973-04-01" @default.
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- W2052626566 title "Temperature-dependent reaction of flufenamic acid with rat erythrocyte membrane" @default.
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- W2052626566 doi "https://doi.org/10.1016/0006-2952(73)90211-6" @default.
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