Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052648118> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2052648118 endingPage "655" @default.
- W2052648118 startingPage "649" @default.
- W2052648118 abstract "Abstract: The complement system consists of a series of serum proteins which interact to facilitate the action of certain classes of antibody and antigen/antibody complexes. Complement may be disturbed by pathological utilisation of one or both of its pathways or by a primary deficiency of an individual component. Most complement proteins exhibit co-dominant inheritance with close linkage to a gene regulating synthesis of that component. Homozygous or (occasionally) heterozygous defects may be associated with clinical syndromes that fall broadly into two categories: (i) immune deficiency with increased susceptibility to infection and (ii) immunological disease, most frequently resembling systemic lupus erythematosus. The basis for the increased incidence of this second group of disorders in patients with complement deficiency is poorly understood. Several mechanisms have been proposed. Firstly, the possibility that the complement defect provides a marker of a more serious, as yet undefined, abnormality of the immune response; secondly, that there is increased susceptibility to infection with immune complex formation and subsequent failure of clearance of these complexes; and thirdly, that the afferent arm of the immune response is impaired. Complement deficiency is suspected when there is reduced total haemolytic complement activity without evidence of classical or alternative pathway activation. The defect may then be further defined by the measurement of individual components in both the patient and other family members. The range of syndromes presently attributed to patients with these defects makes it likely that there will be a progressive increase in the clinical awareness of disease states associated with complement deficiency. Such associations also have important biological implications." @default.
- W2052648118 created "2016-06-24" @default.
- W2052648118 creator A5002974398 @default.
- W2052648118 creator A5049300544 @default.
- W2052648118 date "1982-12-01" @default.
- W2052648118 modified "2023-10-14" @default.
- W2052648118 title "Complement Deficiency and Disease" @default.
- W2052648118 cites W1460551420 @default.
- W2052648118 cites W1510051753 @default.
- W2052648118 cites W1967238055 @default.
- W2052648118 cites W1979129601 @default.
- W2052648118 cites W2010856999 @default.
- W2052648118 cites W2010887039 @default.
- W2052648118 cites W2041375282 @default.
- W2052648118 cites W2045676546 @default.
- W2052648118 cites W2057816117 @default.
- W2052648118 cites W2059329847 @default.
- W2052648118 cites W2059355773 @default.
- W2052648118 cites W2082931016 @default.
- W2052648118 cites W2105760243 @default.
- W2052648118 cites W2118282518 @default.
- W2052648118 cites W2134440342 @default.
- W2052648118 cites W2143286148 @default.
- W2052648118 cites W2336361427 @default.
- W2052648118 cites W4313316237 @default.
- W2052648118 doi "https://doi.org/10.1111/j.1445-5994.1982.tb02659.x" @default.
- W2052648118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6962719" @default.
- W2052648118 hasPublicationYear "1982" @default.
- W2052648118 type Work @default.
- W2052648118 sameAs 2052648118 @default.
- W2052648118 citedByCount "1" @default.
- W2052648118 crossrefType "journal-article" @default.
- W2052648118 hasAuthorship W2052648118A5002974398 @default.
- W2052648118 hasAuthorship W2052648118A5049300544 @default.
- W2052648118 hasConcept C111684460 @default.
- W2052648118 hasConcept C126322002 @default.
- W2052648118 hasConcept C142724271 @default.
- W2052648118 hasConcept C159654299 @default.
- W2052648118 hasConcept C171279029 @default.
- W2052648118 hasConcept C189446657 @default.
- W2052648118 hasConcept C203014093 @default.
- W2052648118 hasConcept C207886595 @default.
- W2052648118 hasConcept C2777327493 @default.
- W2052648118 hasConcept C2779134260 @default.
- W2052648118 hasConcept C2780091579 @default.
- W2052648118 hasConcept C2780368995 @default.
- W2052648118 hasConcept C2910695815 @default.
- W2052648118 hasConcept C71924100 @default.
- W2052648118 hasConcept C8891405 @default.
- W2052648118 hasConceptScore W2052648118C111684460 @default.
- W2052648118 hasConceptScore W2052648118C126322002 @default.
- W2052648118 hasConceptScore W2052648118C142724271 @default.
- W2052648118 hasConceptScore W2052648118C159654299 @default.
- W2052648118 hasConceptScore W2052648118C171279029 @default.
- W2052648118 hasConceptScore W2052648118C189446657 @default.
- W2052648118 hasConceptScore W2052648118C203014093 @default.
- W2052648118 hasConceptScore W2052648118C207886595 @default.
- W2052648118 hasConceptScore W2052648118C2777327493 @default.
- W2052648118 hasConceptScore W2052648118C2779134260 @default.
- W2052648118 hasConceptScore W2052648118C2780091579 @default.
- W2052648118 hasConceptScore W2052648118C2780368995 @default.
- W2052648118 hasConceptScore W2052648118C2910695815 @default.
- W2052648118 hasConceptScore W2052648118C71924100 @default.
- W2052648118 hasConceptScore W2052648118C8891405 @default.
- W2052648118 hasIssue "6" @default.
- W2052648118 hasLocation W20526481181 @default.
- W2052648118 hasLocation W20526481182 @default.
- W2052648118 hasOpenAccess W2052648118 @default.
- W2052648118 hasPrimaryLocation W20526481181 @default.
- W2052648118 hasRelatedWork W1984587156 @default.
- W2052648118 hasRelatedWork W2000574489 @default.
- W2052648118 hasRelatedWork W2020611003 @default.
- W2052648118 hasRelatedWork W2036126415 @default.
- W2052648118 hasRelatedWork W2082187912 @default.
- W2052648118 hasRelatedWork W2099753237 @default.
- W2052648118 hasRelatedWork W2156890640 @default.
- W2052648118 hasRelatedWork W2171497913 @default.
- W2052648118 hasRelatedWork W2952520167 @default.
- W2052648118 hasRelatedWork W29888215 @default.
- W2052648118 hasVolume "12" @default.
- W2052648118 isParatext "false" @default.
- W2052648118 isRetracted "false" @default.
- W2052648118 magId "2052648118" @default.
- W2052648118 workType "article" @default.