FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052650104> ?p ?o ?g. }

• W2052650104 endingPage "1023" @default.
• W2052650104 startingPage "1015" @default.
• W2052650104 abstract "Background: Site-specific protein-DNA complexes vary greatly in structural properties and in the thermodynamic strategy for achieving an appropriate binding free energy. A better understanding of the structural and energetic engineering principles might lead to rational methods for modification or design of such proteins.Results: A novel analysis of ten site-specific protein-DNA complexes reveals a striking correspondence between the degree of imposed DNA distortion and the thermodynamic parameters of each system. For complexes with relatively undistorted DNA, favorable enthalpy change drives unfavorable entropy change, whereas for complexes with highly distorted DNA, unfavorable ΔH° is driven by favorable ΔS°. We show for the first time that protein-DNA associations have isothermal enthalpy-entropy compensation, distinct from temperature-dependent compensation, so ΔH° and ΔS° do not vary independently. All complexes have favorable ΔH° from direct protein-DNA recognition interactions and favorable ΔS° from water release. Systems that strongly distort the DNA nevertheless have net unfavorable ΔH° as the result of molecular strain, primarily associated with the base pair destacking. These systems have little coupled protein folding and the strained interface suffers less immobilization, so ΔS° is net favorable. By contrast, systems with little DNA distortion have net favorable ΔH°, which must be counterbalanced by net unfavorable ΔS°, derived from loss of vibrational entropy (a result of isothermal enthalpy-entropy compensation) and from coupling between DNA binding and protein folding.Conclusions: Isothermal enthalpy-entropy compensation implies that a structurally optimal, unstrained fit is achieved only at the cost of entropically unfavorable immobilization, whereas an enthalpically weaker, strained interface entails smaller entropic penalties." @default.
• W2052650104 created "2016-06-24" @default.
• W2052650104 creator A5017489495 @default.
• W2052650104 creator A5082486570 @default.
• W2052650104 creator A5091449127 @default.
• W2052650104 date "2000-10-01" @default.
• W2052650104 modified "2023-10-17" @default.
• W2052650104 title "Structural and Thermodynamic Strategies for Site-Specific DNA Binding Proteins" @default.
• W2052650104 cites W1533569014 @default.
• W2052650104 cites W1569973595 @default.
• W2052650104 cites W1586722842 @default.
• W2052650104 cites W1847275787 @default.
• W2052650104 cites W1965127482 @default.
• W2052650104 cites W1968278001 @default.
• W2052650104 cites W1969842104 @default.
• W2052650104 cites W1972464599 @default.
• W2052650104 cites W1973316236 @default.
• W2052650104 cites W1974197041 @default.
• W2052650104 cites W1974909022 @default.
• W2052650104 cites W1976363969 @default.
• W2052650104 cites W1980316342 @default.
• W2052650104 cites W1981482769 @default.
• W2052650104 cites W1983678802 @default.
• W2052650104 cites W1986290769 @default.
• W2052650104 cites W1987587101 @default.
• W2052650104 cites W1989430838 @default.
• W2052650104 cites W1994706623 @default.
• W2052650104 cites W1997459080 @default.
• W2052650104 cites W1997657600 @default.
• W2052650104 cites W1998767084 @default.
• W2052650104 cites W2000213161 @default.
• W2052650104 cites W2001898035 @default.
• W2052650104 cites W2007272508 @default.
• W2052650104 cites W2007434518 @default.
• W2052650104 cites W2008846230 @default.
• W2052650104 cites W2012121208 @default.
• W2052650104 cites W2015674403 @default.
• W2052650104 cites W2020610229 @default.
• W2052650104 cites W2021163287 @default.
• W2052650104 cites W2029167106 @default.
• W2052650104 cites W2034755896 @default.
• W2052650104 cites W2035797443 @default.
• W2052650104 cites W2036580178 @default.
• W2052650104 cites W2039478144 @default.
• W2052650104 cites W2045854702 @default.
• W2052650104 cites W2046278558 @default.
• W2052650104 cites W2051920745 @default.
• W2052650104 cites W2051927163 @default.
• W2052650104 cites W2052221476 @default.
• W2052650104 cites W2056192634 @default.
• W2052650104 cites W2060816361 @default.
• W2052650104 cites W2066099672 @default.
• W2052650104 cites W2070017301 @default.
• W2052650104 cites W2087640316 @default.
• W2052650104 cites W2090393756 @default.
• W2052650104 cites W2094494277 @default.
• W2052650104 cites W2098089372 @default.
• W2052650104 cites W2100305057 @default.
• W2052650104 cites W2103847199 @default.
• W2052650104 cites W2123768455 @default.
• W2052650104 cites W2135735638 @default.
• W2052650104 cites W2135995702 @default.
• W2052650104 cites W2140854179 @default.
• W2052650104 cites W2171878324 @default.
• W2052650104 doi "https://doi.org/10.1016/s0969-2126(00)00501-3" @default.
• W2052650104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11080623" @default.
• W2052650104 hasPublicationYear "2000" @default.
• W2052650104 type Work @default.
• W2052650104 sameAs 2052650104 @default.
• W2052650104 citedByCount "242" @default.
• W2052650104 countsByYear W20526501042012 @default.
• W2052650104 countsByYear W20526501042013 @default.
• W2052650104 countsByYear W20526501042014 @default.
• W2052650104 countsByYear W20526501042015 @default.
• W2052650104 countsByYear W20526501042016 @default.
• W2052650104 countsByYear W20526501042017 @default.
• W2052650104 countsByYear W20526501042018 @default.
• W2052650104 countsByYear W20526501042019 @default.
• W2052650104 countsByYear W20526501042020 @default.
• W2052650104 countsByYear W20526501042021 @default.
• W2052650104 countsByYear W20526501042022 @default.
• W2052650104 countsByYear W20526501042023 @default.
• W2052650104 crossrefType "journal-article" @default.
• W2052650104 hasAuthorship W2052650104A5017489495 @default.
• W2052650104 hasAuthorship W2052650104A5082486570 @default.
• W2052650104 hasAuthorship W2052650104A5091449127 @default.
• W2052650104 hasBestOaLocation W20526501041 @default.
• W2052650104 hasConcept C106301342 @default.
• W2052650104 hasConcept C119599485 @default.
• W2052650104 hasConcept C121332964 @default.
• W2052650104 hasConcept C12554922 @default.
• W2052650104 hasConcept C127413603 @default.
• W2052650104 hasConcept C185581394 @default.
• W2052650104 hasConcept C185592680 @default.
• W2052650104 hasConcept C204328495 @default.
• W2052650104 hasConcept C2776545253 @default.
• W2052650104 hasConcept C3288061 @default.
• W2052650104 hasConcept C552990157 @default.

• next