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- W2052655322 abstract "Non-specific inhibition of prostaglandin (PG) synthesis reduces elevated pulmonary artery pressure (PAP) in animal models of newborn sepsis. We hypothesized that Tx was the PG which mediated the septic pulmonary hypertension, and investigated the effects of selective inhibition of Tx synthetase during Group B Streptococcal (GBS) sepsis in piglets. 4 piglets were anesthetized, intubated, ventilated and instrumented. Plasma Tx and prostacyclin (PC) metabolites were determined by RIA. Pulmonary hypertension was induced by continuous infusion of GBS. After induction of sepsis, PAP rose from 13±2 (SEM) to 42±5 mmHg, and cardiac output (CO) dropped from 104±6 to 52±6. BP remained unchanged. Concurrently, TxB2 levels rose from 451±264 to 3370±610 pg/ml (p<0.05) and 6 keto PGF1α levels rose from 323±55 to 1322±569. While GBS infusion continued, a thromboxane synthetase inhibitor, dazemgrel (Dz)(UK 38485) was then administered at 1 mg/kg. In response to treatment, PAP decreased rapidly to 16±1 mmHg, BP and CO remained stable. TxB2 levels dropped to 1960±360 and 6 keto PGF1α (a prostacyclin metabolite) levels increased to 2090±363. Conclusions: 1.GBS elevated PAP in piglets while raising both TxB2 and PC metabolites. 2. Dz selectively reduced TxB2 and shunted Pg production towards PC. 3. Dz preferentially diminished PAP during GBS sepsis. 4. Selective inhibition of specific prostaglandins may benefit septic infants with elevated PAP." @default.
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- W2052655322 date "1985-04-01" @default.
- W2052655322 modified "2023-10-18" @default.
- W2052655322 title "373 SELECTIVE INHIBITION OF THROMBOXANE (Tx) SYNTHETASE PREFERENTIALLY REDUCES SEPTIC PULMONARY HYPERTENSION IN PIGLETS" @default.
- W2052655322 doi "https://doi.org/10.1203/00006450-198504000-00403" @default.
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